The use of high-sensitivity assays for C-reactive protein in clinical practice

Kiran Musunuru, Brian G Kral, Roger S Blumenthal, Valentin Fuster, Catherine Y. Campbell, Ty J. Gluckman, Richard A. Lange, Eric J. Topol, James T. Willerson, Milind Y. Desai, Michael H. Davidson, Samia Mora

Research output: Contribution to journalArticle

Abstract

High-sensitivity assays that accurately measure levels of the inflammatory biomarker C-reactive protein have been proposed for use in assessments of risk for cardiovascular disease (CVD). A growing body of evidence supports recommendations for these tests in selected asymptomatic individuals deemed to be at intermediate risk of CVD according to traditional risk-factor assessments and who do not already warrant chronic treatment with aspirin and statin therapy. Data suggests that these high-sensitivity assays should be used in combination with measurements of LDL-cholesterol levels to assist risk stratification of selected patients for prevention of CVD.

Original languageEnglish (US)
Pages (from-to)621-635
Number of pages15
JournalNature Clinical Practice Cardiovascular Medicine
Volume5
Issue number10
DOIs
StatePublished - 2008

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C-Reactive Protein
Cardiovascular Diseases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Aspirin
Biomarkers
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The use of high-sensitivity assays for C-reactive protein in clinical practice. / Musunuru, Kiran; Kral, Brian G; Blumenthal, Roger S; Fuster, Valentin; Campbell, Catherine Y.; Gluckman, Ty J.; Lange, Richard A.; Topol, Eric J.; Willerson, James T.; Desai, Milind Y.; Davidson, Michael H.; Mora, Samia.

In: Nature Clinical Practice Cardiovascular Medicine, Vol. 5, No. 10, 2008, p. 621-635.

Research output: Contribution to journalArticle

Musunuru, K, Kral, BG, Blumenthal, RS, Fuster, V, Campbell, CY, Gluckman, TJ, Lange, RA, Topol, EJ, Willerson, JT, Desai, MY, Davidson, MH & Mora, S 2008, 'The use of high-sensitivity assays for C-reactive protein in clinical practice', Nature Clinical Practice Cardiovascular Medicine, vol. 5, no. 10, pp. 621-635. https://doi.org/10.1038/ncpcardio1322
Musunuru, Kiran ; Kral, Brian G ; Blumenthal, Roger S ; Fuster, Valentin ; Campbell, Catherine Y. ; Gluckman, Ty J. ; Lange, Richard A. ; Topol, Eric J. ; Willerson, James T. ; Desai, Milind Y. ; Davidson, Michael H. ; Mora, Samia. / The use of high-sensitivity assays for C-reactive protein in clinical practice. In: Nature Clinical Practice Cardiovascular Medicine. 2008 ; Vol. 5, No. 10. pp. 621-635.
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