The use of genetically modified embryonic stem cells to generate transgenic mice

M. V. Pryzhkova, I. R. Zakeeva, A. V. Kibardin, G. P. Georgier, S. L. Kiselev

Research output: Contribution to journalArticle

Abstract

Targeted genetic modification of embryonic stem cells (ESC) was used to obtain nondifferentiated cell clones containing the foreign genetic material in the genome. It was demonstrated that transgenic animals may be obtained by ESC injection in preimplantation embryos and subsequent transplantation of the embryos into a recipient female. Using this method, we constructed chimeric animals with a modified genome.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalGenetika
Volume40
Issue number3
StatePublished - Dec 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The use of genetically modified embryonic stem cells to generate transgenic mice'. Together they form a unique fingerprint.

  • Cite this

    Pryzhkova, M. V., Zakeeva, I. R., Kibardin, A. V., Georgier, G. P., & Kiselev, S. L. (2004). The use of genetically modified embryonic stem cells to generate transgenic mice. Genetika, 40(3), 311-315.