The use of genetically modified embryonic stem cells to generate transgenic mice

Marina Pryzhkova, I. R. Zakeeva, A. V. Kibardin, G. P. Georgier, S. L. Kiselev

Research output: Contribution to journalArticle

Abstract

Targeted genetic modification of embryonic stem cells (ESC) was used to obtain nondifferentiated cell clones containing the foreign genetic material in the genome. It was demonstrated that transgenic animals may be obtained by ESC injection in preimplantation embryos and subsequent transplantation of the embryos into a recipient female. Using this method, we constructed chimeric animals with a modified genome.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalGenetika
Volume40
Issue number3
StatePublished - Dec 1 2004
Externally publishedYes

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Embryonic Stem Cells
Transgenic Mice
Genome
Genetically Modified Animals
Blastocyst
Embryonic Structures
Clone Cells
Transplantation
Injections
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pryzhkova, M., Zakeeva, I. R., Kibardin, A. V., Georgier, G. P., & Kiselev, S. L. (2004). The use of genetically modified embryonic stem cells to generate transgenic mice. Genetika, 40(3), 311-315.

The use of genetically modified embryonic stem cells to generate transgenic mice. / Pryzhkova, Marina; Zakeeva, I. R.; Kibardin, A. V.; Georgier, G. P.; Kiselev, S. L.

In: Genetika, Vol. 40, No. 3, 01.12.2004, p. 311-315.

Research output: Contribution to journalArticle

Pryzhkova, M, Zakeeva, IR, Kibardin, AV, Georgier, GP & Kiselev, SL 2004, 'The use of genetically modified embryonic stem cells to generate transgenic mice', Genetika, vol. 40, no. 3, pp. 311-315.
Pryzhkova M, Zakeeva IR, Kibardin AV, Georgier GP, Kiselev SL. The use of genetically modified embryonic stem cells to generate transgenic mice. Genetika. 2004 Dec 1;40(3):311-315.
Pryzhkova, Marina ; Zakeeva, I. R. ; Kibardin, A. V. ; Georgier, G. P. ; Kiselev, S. L. / The use of genetically modified embryonic stem cells to generate transgenic mice. In: Genetika. 2004 ; Vol. 40, No. 3. pp. 311-315.
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