The use of clomiphene citrate

J. Garcia, G. S.A.C. Jones Wentz

Research output: Contribution to journalArticlepeer-review

158 Scopus citations


255 women received clomiphene citrate during a 10-year period. Fifty-six were treated diagnostically and 199 therapeutically for infertility. It is concluded that clomiphene may aid in confirming the diagnosis and establishing a prognosis in patients with primary or secondary amenorrhea. The success of clomiphene therapy in patients with anovulatory infertility is related to the etiologic factor responsible for the anovulation, but results can be improved by adjustment of the therapeutic regimen used. In the present series, 48% of the patients who ovulated became pregnant, and 25.3% of the pregnancies were miscarried. Those patients who ovulated spontaneously and became pregnant after having discontinued clomiphene therapy showed only a 10% abortion rate. A review of the results indicates that the ovulation rate and the pregnancy rate can be improved if adjustments are made in therapy to ensure normal follicular maturation and corpus luteum function.

Original languageEnglish (US)
Pages (from-to)707-717
Number of pages11
JournalFertility and sterility
Issue number7
StatePublished - 1977

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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