The use of a modified Dakin's solution (sodium hypochlorite) in the treatment of Vibrio vulnificus infection

Stephen M. Milner, John P. Heggers

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first clinical use of a modified Dakin's solution (0.025% sodium hypochlorite [NaOCl]) to halt the progress of severe cutaneous Vibrio vulnificus infection in a critically ill patient. The regimen used arose from an initial in vitro study designed to examine the sensitivity of Vibrio species to topical antimicrobial agents. Twenty-eight wound isolates were tested against the following eight topical preparations: silver sulfadiazine (Silvadene), nitrofurazone, mupirocin ointment (Bactroban), polymyxin B/bacitracin, mafenide acetate (Sulfamylon), nystatin/Silvadene, nystatin/polymyxin B/bacitracin, and 0.025% NaOCl solution. The results showed that V vulnificus, along with the other 18 Vibrio species tested, was most sensitive to the modified NaOCl solution.

Original languageEnglish (US)
Pages (from-to)10-12
Number of pages3
JournalWilderness and Environmental Medicine
Volume10
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Emergency Medicine
  • Public Health, Environmental and Occupational Health

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