The use of a global statistical approach for the design and data analysis of clinical trials with multiple primary outcomes

Peng Huang, Robert F. Woolson, Ann Charlotte Granholm

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Determining whether one treatment is preferred over others is a major goal of many clinical studies but can be complicated by the situation when no single outcome is sufficient to make the judgment. We present a useful global statistical test technique and the corresponding global treatment effect (GTE) measure for assessing treatment's global preference when multiple outcomes are evaluated together. Applications of these techniques in clinical trial design and data analysis are illustrated.

Original languageEnglish (US)
Title of host publicationExperimental Stroke
PublisherBentham Science Publishers Ltd.
Pages100-108
Number of pages9
ISBN (Print)9781608056668
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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