The urinary excretion of nucleosides of ribonucleic acid by patients with advanced cancer

T. Phillip Waalkes, Charles W. Gehrke, Robert W. Zumwalt, Sai Y. Chang, Duane B. Lakings, Douglass C. Tormey, David L. Ahmann, Charles G. Moertel

Research output: Contribution to journalArticle

Abstract

By means of a sensitive and specific method utilizing gas‐liquid chromatography, the excretion levels for three nucleosides, degradation minor base products of ribonucleic acid, primarily transfer ribonucleic acid, were determined in 24–hour urine specimens from over 200 patients with solid tumor malignancies. These nucleosides were N2, N2‐dimethylguanosine, 1–methylinosine, and pseudouridine. When compared to normal control values, elevated levels of these compounds were found for patients in each of several tumor types studied. Increases in pseudouridine excretion suggest increased tumor transfer ribonucleic acid turnover; in addition, for the methylated nucleosides, higher than normal values may reflect enhanced transfer ribonucleic acid methylase activity of the neoplastic cells.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalCancer
Volume36
Issue number2
DOIs
StatePublished - Aug 1975

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Waalkes, T. P., Gehrke, C. W., Zumwalt, R. W., Chang, S. Y., Lakings, D. B., Tormey, D. C., Ahmann, D. L., & Moertel, C. G. (1975). The urinary excretion of nucleosides of ribonucleic acid by patients with advanced cancer. Cancer, 36(2), 390-398. https://doi.org/10.1002/1097-0142(197508)36:2<390::AID-CNCR2820360214>3.0.CO;2-C