The untapped potential of proteomic analysis in pediatric pulmonary hypertension

Research output: Contribution to journalReview article

Abstract

Analysis of the human proteome has become increasingly sophisticated, and offers invaluable potential insight into the pathophysiology of human disease. The increasing standardization of methods, speed, and sophistication of mass spectrometric analysis, availability of reliable antibodies, and dissemination of information among the scientific community has allowed for exponential growth of our knowledge base. The continued effort to provide a molecular explanation for future medical applications based on biomarker discovery is epitomized by the outstanding efforts of the human proteome project, whose goal is to generate a map of the human proteome. However, proteomic analysis is underrepresented in pediatric illness; given the unique challenges of research in the pediatric population, proteomic analysis represents enormous untapped potential, especially in the further elucidation of the pathophysiology of rare diseases such as pulmonary hypertension (PH). In this article, we will describe the unique challenge of pediatric research, the importance of alternative avenues such as proteomics for in-depth analysis of pediatric pathobiology at the cellular level, the specific need for proteomic investigation of pediatric PH, the current status of PH proteomics, and future directions.

Original languageEnglish (US)
Pages (from-to)862-874
Number of pages13
JournalProteomics - Clinical Applications
Volume8
Issue number11-12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Biomarker
  • Cardiology
  • Pediatrics
  • Proteomics
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Clinical Biochemistry

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