The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges

Cory Abate-Shen, Powel H. Brown, Nancy H. Colburn, Eugene W. Gerner, Jeffery E. Green, Martin Lipkin, William G. Nelson, David Threadgill

Research output: Contribution to journalReview article

Abstract

The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalCancer Prevention Research
Volume1
Issue number3
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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