The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges

Cory Abate-Shen; Powel H. Brown; Nancy H. Colburn; Eugene W. Gerner; Jeffery E. Green; Martin Lipkin; William G. Nelson; David Threadgill

doi:10.1158/1940-6207.CAPR-08-0076

The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges

Cory Abate-Shen, Powel H. Brown, Nancy H. Colburn, Eugene W. Gerner, Jeffery E. Green, Martin Lipkin, William G. Nelson, David Threadgill

School of Medicine

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Cancer Prevention Research
Volume	1
Issue number	3
DOIs	https://doi.org/10.1158/1940-6207.CAPR-08-0076
State	Published - Aug 2008

ASJC Scopus subject areas

General Medicine

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title = "The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges",

abstract = "The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.",

author = "Cory Abate-Shen and Brown, {Powel H.} and Colburn, {Nancy H.} and Gerner, {Eugene W.} and Green, {Jeffery E.} and Martin Lipkin and Nelson, {William G.} and David Threadgill",

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AU - Gerner, Eugene W.

AU - Green, Jeffery E.

AU - Lipkin, Martin

AU - Nelson, William G.

AU - Threadgill, David

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AB - The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

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The untapped potential of genetically engineered mouse models in chemoprevention research: Opportunities and challenges

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