The unknown burden and cost of celiac disease in the U.S

Douglas Bradford Mogul, Yusuke Nakamura, Jaein Seo, Barri Blauvelt, John F.P. Bridges

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Introduction: Celiac disease is an autoimmune disease that results from exposure to gluten in genetically susceptible individuals and leads to a range of gastrointestinal and extraintestinal symptoms. Areas covered: In order to evaluate the literature with respect to burden associated with celiac disease in the U.S. and identify any knowledge gaps, we performed a literature review of journal articles published between 2000–2016. We note that celiac disease is a prevalent condition associated with a significant burden of disease through its impact on morbidity, quality of life, as well as through increased costs associated with its diagnosis and management. At the same time, knowledge gaps exist in our understanding of the precise epidemiologic burden in the U.S.; the trade-offs between burden and benefit of a gluten-free diet; and better estimation of the costs of diagnosis, treatment and management.Expert commentary: Additional research is necessary to better understand these gaps to be able to reduce burden of celiac disease, particularly the impact on health-related quality of life and the costs associated with inaccurate or delayed diagnoses and insufficient treatment of disease.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Issue number2
StatePublished - Mar 4 2017


  • burden of disease
  • Celiac disease
  • cost of illness
  • gluten
  • quality of life

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)


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