The triggering, curving and stopping of excitable waves during cell migration

Sayak Bhattacharya, Pablo A Iglesias

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent advances in the understanding of cell migration in amoeboid cells have demonstrated the existence of excitable dynamics in the regulation of the extension and retraction of pseudopodia. In particular, traveling waves of biochemical signaling and actin polymerization have been observed in a number of different cell types. These waves appear to be triggered at a point on the cell cortex and propagate along the perimeter of the cell, pushing the membrane outward to create pseudopods. These waves, however, do not always spread throughout the entire cell cortex. More often than not, they stop after traveling a certain distance along the membrane. In this paper, we look at the factors that create the traveling front, and influence the stopping of the wave. We show that the speed of the wave is controlled by the initial set point of the excitable system, as well as the existence of a critical point for each system, that governs the stopping of the wave.

Original languageEnglish (US)
Title of host publication2017 51st Annual Conference on Information Sciences and Systems, CISS 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509047802
DOIs
StatePublished - May 10 2017
Event51st Annual Conference on Information Sciences and Systems, CISS 2017 - Baltimore, United States
Duration: Mar 22 2017Mar 24 2017

Other

Other51st Annual Conference on Information Sciences and Systems, CISS 2017
CountryUnited States
CityBaltimore
Period3/22/173/24/17

Fingerprint

Membranes
Membrane
Polymerization
Factors
Critical point
Traveling wave

Keywords

  • Cell migration
  • Excitable systems
  • Wave propagation

ASJC Scopus subject areas

  • Signal Processing
  • Information Systems and Management
  • Computer Networks and Communications
  • Information Systems

Cite this

Bhattacharya, S., & Iglesias, P. A. (2017). The triggering, curving and stopping of excitable waves during cell migration. In 2017 51st Annual Conference on Information Sciences and Systems, CISS 2017 [7926103] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CISS.2017.7926103

The triggering, curving and stopping of excitable waves during cell migration. / Bhattacharya, Sayak; Iglesias, Pablo A.

2017 51st Annual Conference on Information Sciences and Systems, CISS 2017. Institute of Electrical and Electronics Engineers Inc., 2017. 7926103.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bhattacharya, S & Iglesias, PA 2017, The triggering, curving and stopping of excitable waves during cell migration. in 2017 51st Annual Conference on Information Sciences and Systems, CISS 2017., 7926103, Institute of Electrical and Electronics Engineers Inc., 51st Annual Conference on Information Sciences and Systems, CISS 2017, Baltimore, United States, 3/22/17. https://doi.org/10.1109/CISS.2017.7926103
Bhattacharya S, Iglesias PA. The triggering, curving and stopping of excitable waves during cell migration. In 2017 51st Annual Conference on Information Sciences and Systems, CISS 2017. Institute of Electrical and Electronics Engineers Inc. 2017. 7926103 https://doi.org/10.1109/CISS.2017.7926103
Bhattacharya, Sayak ; Iglesias, Pablo A. / The triggering, curving and stopping of excitable waves during cell migration. 2017 51st Annual Conference on Information Sciences and Systems, CISS 2017. Institute of Electrical and Electronics Engineers Inc., 2017.
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