The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease

Beth Ann Zarkin, Keith D. Lillemoe, John L Cameron, Philip N. Effron, Thomas Magnuson, Henry A. Pitt

Research output: Contribution to journalArticle

Abstract

The association of Streptococcus bovis endocarditis and colon carcinoma has been reported previously in small series in the medical, but not surgical, literature. Although the fecal carriage rate of S. bovis increases with colonic pathology, no explanation exists for the development of bacteremia in these cases. To explore the possible contribution of hepatic dysfunction to the development of portal and systemic bacteremia, the incidence of both colonic pathology and liver disease or dysfunction was determined in 92 patients with S. bovis endocarditis and/or bacteremia. Colonic and liver evaluation had been undertaken in 47% and 93% of patients, respectively. Among these patients, colonic pathology was identified in 51%, and liver disease or dysfunction was documented in 56%. Either the underlying colonic disease or alterations in hepatic secretion of bile salts or immunoglobulins may promote the overgrowth of S. bovis and its translocation from the intestinal lumen into the portal venous system. A compromised hepatic reticuloendothelial system may then contribute to the development of S. bovis septicemia and subsequent endocarditis. We conclude that S. bovis bacteremia is an indication to the clinician of the possibility of underlying liver disease as well as colon pathology.

Original languageEnglish (US)
Pages (from-to)786-791
Number of pages6
JournalAnnals of Surgery
Volume211
Issue number6
StatePublished - 1990

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Streptococcus bovis
Colonic Diseases
Bacteremia
Liver Diseases
Pathology
Endocarditis
Liver
Colon
Portal System
Mononuclear Phagocyte System
Bile Acids and Salts
Immunoglobulins
Sepsis
Carcinoma
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Zarkin, B. A., Lillemoe, K. D., Cameron, J. L., Effron, P. N., Magnuson, T., & Pitt, H. A. (1990). The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease. Annals of Surgery, 211(6), 786-791.

The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease. / Zarkin, Beth Ann; Lillemoe, Keith D.; Cameron, John L; Effron, Philip N.; Magnuson, Thomas; Pitt, Henry A.

In: Annals of Surgery, Vol. 211, No. 6, 1990, p. 786-791.

Research output: Contribution to journalArticle

Zarkin, BA, Lillemoe, KD, Cameron, JL, Effron, PN, Magnuson, T & Pitt, HA 1990, 'The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease', Annals of Surgery, vol. 211, no. 6, pp. 786-791.
Zarkin, Beth Ann ; Lillemoe, Keith D. ; Cameron, John L ; Effron, Philip N. ; Magnuson, Thomas ; Pitt, Henry A. / The triad of Streptococcus bovis bacteremia, colonic pathology, and liver disease. In: Annals of Surgery. 1990 ; Vol. 211, No. 6. pp. 786-791.
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