The treatment of candidemia

Mark J. Dinubile; Corrado Girmenia; Pietro Martino; Richard D. Cofsky; C. M. Tang; P. Howe; D. W. Crook; John H. Rex; John E. Bennett; Alan M. Sugar; Françoise Meunier

doi:10.1056/NEJM199504203321614

The treatment of candidemia

Mark J. Dinubile, Corrado Girmenia, Pietro Martino, Richard D. Cofsky, C. M. Tang, P. Howe, D. W. Crook, John H. Rex, John E. Bennett, Alan M. Sugar, Françoise Meunier

School of Medicine

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

To the Editor: The prospective study by Rex and colleagues (Nov. 17 issue)¹ comparing amphotericin B with fluconazole for the treatment of candidemia concludes that the two treatments are equally effective. This opinion is echoed and endorsed in the accompanying editorial.² Unfortunately, this randomized, controlled study may in some respects provide the right answer to the wrong question. It may be misconstrued as a mandate for the treatment of all patients with candidemia. Overall, patients with candidemia treated with either amphotericin B or fluconazole do not appear to have fared much better than untreated historical controls.³ I contend that no.

Original language	English (US)
Pages (from-to)	1100-1102
Number of pages	3
Journal	New England Journal of Medicine
Volume	332
Issue number	16
DOIs	https://doi.org/10.1056/NEJM199504203321614
State	Published - Apr 20 1995

ASJC Scopus subject areas

General Medicine

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title = "The treatment of candidemia",

abstract = "To the Editor: The prospective study by Rex and colleagues (Nov. 17 issue)1 comparing amphotericin B with fluconazole for the treatment of candidemia concludes that the two treatments are equally effective. This opinion is echoed and endorsed in the accompanying editorial.2 Unfortunately, this randomized, controlled study may in some respects provide the right answer to the wrong question. It may be misconstrued as a mandate for the treatment of all patients with candidemia. Overall, patients with candidemia treated with either amphotericin B or fluconazole do not appear to have fared much better than untreated historical controls.3 I contend that no.",

author = "Dinubile, {Mark J.} and Corrado Girmenia and Pietro Martino and Cofsky, {Richard D.} and Tang, {C. M.} and P. Howe and Crook, {D. W.} and Rex, {John H.} and Bennett, {John E.} and Sugar, {Alan M.} and Fran{\c c}oise Meunier",

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language = "English (US)",

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T1 - The treatment of candidemia

AU - Dinubile, Mark J.

AU - Girmenia, Corrado

AU - Martino, Pietro

AU - Cofsky, Richard D.

AU - Tang, C. M.

AU - Howe, P.

AU - Crook, D. W.

AU - Rex, John H.

AU - Bennett, John E.

AU - Sugar, Alan M.

AU - Meunier, Françoise

PY - 1995/4/20

Y1 - 1995/4/20

N2 - To the Editor: The prospective study by Rex and colleagues (Nov. 17 issue)1 comparing amphotericin B with fluconazole for the treatment of candidemia concludes that the two treatments are equally effective. This opinion is echoed and endorsed in the accompanying editorial.2 Unfortunately, this randomized, controlled study may in some respects provide the right answer to the wrong question. It may be misconstrued as a mandate for the treatment of all patients with candidemia. Overall, patients with candidemia treated with either amphotericin B or fluconazole do not appear to have fared much better than untreated historical controls.3 I contend that no.

AB - To the Editor: The prospective study by Rex and colleagues (Nov. 17 issue)1 comparing amphotericin B with fluconazole for the treatment of candidemia concludes that the two treatments are equally effective. This opinion is echoed and endorsed in the accompanying editorial.2 Unfortunately, this randomized, controlled study may in some respects provide the right answer to the wrong question. It may be misconstrued as a mandate for the treatment of all patients with candidemia. Overall, patients with candidemia treated with either amphotericin B or fluconazole do not appear to have fared much better than untreated historical controls.3 I contend that no.

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The treatment of candidemia

Abstract

ASJC Scopus subject areas

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