The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

Julian Borrow; Vincent P. Stanton; J. Michael Andresen; Reinhard Becher; Frederick G. Behm; Raju S K Chaganti; Curt I. Civin; Christine Disteche; Ian Dubé; Anna Marie Frischauf; Doug Horsman; Felix Mitelman; Stefano Volinia; Ann E. Watmore; David E. Housman

doi:10.1038/ng0996-33

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

Julian Borrow, Vincent P. Stanton, J. Michael Andresen, Reinhard Becher, Frederick G. Behm, Raju S K Chaganti, Curt I. Civin, Christine Disteche, Ian Dubé, Anna Marie Frischauf, Doug Horsman, Felix Mitelman, Stefano Volinia, Ann E. Watmore, David E. Housman

School of Medicine

Research output: Contribution to journal › Article › peer-review

613 Scopus citations

Abstract

The recurrent translocation t(8;16)(p11;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ-CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBR. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Nature Genetics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/ng0996-33
State	Published - Sep 1996

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Borrow, J., Stanton, V. P., Andresen, J. M., Becher, R., Behm, F. G., Chaganti, R. S. K., Civin, C. I., Disteche, C., Dubé, I., Frischauf, A. M., Horsman, D., Mitelman, F., Volinia, S., Watmore, A. E., & Housman, D. E. (1996). The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nature Genetics, 14(1), 33-41. https://doi.org/10.1038/ng0996-33

Borrow, J, Stanton, VP, Andresen, JM, Becher, R, Behm, FG, Chaganti, RSK, Civin, CI, Disteche, C, Dubé, I, Frischauf, AM, Horsman, D, Mitelman, F, Volinia, S, Watmore, AE & Housman, DE 1996, 'The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein', Nature Genetics, vol. 14, no. 1, pp. 33-41. https://doi.org/10.1038/ng0996-33

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title = "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein",

abstract = "The recurrent translocation t(8;16)(p11;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ-CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBR. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation.",

author = "Julian Borrow and Stanton, {Vincent P.} and Andresen, {J. Michael} and Reinhard Becher and Behm, {Frederick G.} and Chaganti, {Raju S K} and Civin, {Curt I.} and Christine Disteche and Ian Dub{\'e} and Frischauf, {Anna Marie} and Doug Horsman and Felix Mitelman and Stefano Volinia and Watmore, {Ann E.} and Housman, {David E.}",

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AU - Becher, Reinhard

AU - Behm, Frederick G.

AU - Chaganti, Raju S K

AU - Civin, Curt I.

AU - Disteche, Christine

AU - Dubé, Ian

AU - Frischauf, Anna Marie

AU - Horsman, Doug

AU - Mitelman, Felix

AU - Volinia, Stefano

AU - Watmore, Ann E.

AU - Housman, David E.

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The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

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