The transcriptional program in the response of human fibroblasts to serum

Vishwanath R. Iyer, Michael B. Eisen, Douglas T. Ross, Greg Schuler, Troy Moore, Jeffrey C.F. Lee, Jeffrey M. Trent, Louis M. Staudt, James Hudson, Mark S. Boguski, Deval Lashkari, Dari Shalon, David Botstein, Patrick O. Brown

Research output: Contribution to journalArticle

Abstract

The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalScience
Volume283
Issue number5398
DOIs
StatePublished - Jan 1 1999

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ASJC Scopus subject areas

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Cite this

Iyer, V. R., Eisen, M. B., Ross, D. T., Schuler, G., Moore, T., Lee, J. C. F., Trent, J. M., Staudt, L. M., Hudson, J., Boguski, M. S., Lashkari, D., Shalon, D., Botstein, D., & Brown, P. O. (1999). The transcriptional program in the response of human fibroblasts to serum. Science, 283(5398), 83-87. https://doi.org/10.1126/science.283.5398.83