The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning

Li E. Cheng, Jiangyang Zhang, Randall R Reed

Research output: Contribution to journalArticle

Abstract

The dorsal midline structure is critical for patterning the developing central nervous system (CNS). We show here that Zfp423/OAZ, a multiple zinc-finger transcription factor involved in both OE/EBF and BMP-signaling pathways, is required for the proper formation of forebrain and hindbrain midline structures. During embryogenesis, OAZ is highly expressed at the dorsal neuroepithelium flanking the roof plate. OAZ-deficient mice are ataxic, attributed to the reduction of the cerebellar vermis and some regions of the hemispheres. Characterization of postnatal cerebellar development shows defects in Purkinje cell differentiation and granule cell proliferation. In the forebrain, dorsal telencephalic commissural neurons project axons, but these axons fail to cross the midline and midline glial cells are abnormally distributed. Moreover, there are malformations in midline structures including the septum, thalamus and hypothalamus, suggesting a pivotal role of OAZ in CNS midline patterning.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalDevelopmental Biology
Volume307
Issue number1
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Fingerprint

Prosencephalon
Axons
Transcription Factors
Central Nervous System
Telencephalon
Rhombencephalon
Purkinje Cells
Zinc Fingers
Thalamus
Neuroglia
Hypothalamus
Embryonic Development
Cell Differentiation
Cell Proliferation
Neurons
Cerebellar Vermis

Keywords

  • Ataxia
  • BMP-signaling
  • Cerebellum
  • Corpus callosum
  • Midline
  • OAZ
  • Transcription factor
  • Zinc finger

ASJC Scopus subject areas

  • Developmental Biology

Cite this

The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. / Cheng, Li E.; Zhang, Jiangyang; Reed, Randall R.

In: Developmental Biology, Vol. 307, No. 1, 01.07.2007, p. 43-52.

Research output: Contribution to journalArticle

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