The traceless Staudinger ligation for indirect 18F- radiolabelling

Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journalArticlepeer-review

Abstract

The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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