The traceless Staudinger ligation for indirect 18F- radiolabelling

Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journalArticle

Abstract

The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J., & Gouverneur, V. (2011). The traceless Staudinger ligation for indirect 18F- radiolabelling. Organic and Biomolecular Chemistry, 9(1), 136-140. https://doi.org/10.1039/c0ob00564a