The traceless Staudinger ligation for indirect 18F- radiolabelling

Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journalArticle

Abstract

The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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phosphine
phosphines
Ligation
Molecules
Radio
molecules

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J., & Gouverneur, V. (2011). The traceless Staudinger ligation for indirect 18F- radiolabelling. Organic and Biomolecular Chemistry, 9(1), 136-140. https://doi.org/10.1039/c0ob00564a

The traceless Staudinger ligation for indirect 18F- radiolabelling. / Carroll, Laurence; Boldon, Sophie; Bejot, Romain; Moore, Jane E.; Declerck, Jérôme; Gouverneur, Véronique.

In: Organic and Biomolecular Chemistry, Vol. 9, No. 1, 01.01.2011, p. 136-140.

Research output: Contribution to journalArticle

Carroll, L, Boldon, S, Bejot, R, Moore, JE, Declerck, J & Gouverneur, V 2011, 'The traceless Staudinger ligation for indirect 18F- radiolabelling', Organic and Biomolecular Chemistry, vol. 9, no. 1, pp. 136-140. https://doi.org/10.1039/c0ob00564a
Carroll, Laurence ; Boldon, Sophie ; Bejot, Romain ; Moore, Jane E. ; Declerck, Jérôme ; Gouverneur, Véronique. / The traceless Staudinger ligation for indirect 18F- radiolabelling. In: Organic and Biomolecular Chemistry. 2011 ; Vol. 9, No. 1. pp. 136-140.
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