The traceless Staudinger ligation for indirect 18F- radiolabelling

Laurence Carroll; Sophie Boldon; Romain Bejot; Jane E. Moore; Jérôme Declerck; Véronique Gouverneur

doi:10.1039/c0ob00564a

The traceless Staudinger ligation for indirect ¹⁸F- radiolabelling

Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore, Jérôme Declerck, Véronique Gouverneur

School of Medicine

Research output: Contribution to journal › Article

Abstract

The Staudinger ligation of phosphine-substituted thioesters with ¹⁸F-fluoroethylazide has been successfully applied to access ¹⁸F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.

Original language	English (US)
Pages (from-to)	136-140
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1039/c0ob00564a
State	Published - Jan 1 2011

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J., & Gouverneur, V. (2011). The traceless Staudinger ligation for indirect ¹⁸F- radiolabelling. Organic and Biomolecular Chemistry, 9(1), 136-140. https://doi.org/10.1039/c0ob00564a

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Access to Document

10.1039/c0ob00564a