The TORC1-activated proteins, p70S6K and GRB10, regulate IL-4 signaling and M2 macrophage polarization by modulating phosphorylation of insulin receptor substrate-2

Medicine & Life Sciences

• GRB10 Adaptor Protein 100%
• 70-kDa Ribosomal Protein S6 Kinases 65%
• Insulin Receptor Substrate Proteins 64%
• Mechanistic Target of Rapamycin Complex 1 62%
• Interleukin-4 45%
• Macrophages 34%
• Phosphorylation 34%
• Tyrosine 20%
• Serine 13%
• Interleukin-4 Receptors 6%
• Gene Expression 5%
• Inflammation 5%
• Ubiquitin-Protein Ligases 5%
• Lung 4%
• Phosphoric Monoester Hydrolases 4%
• Genes 3%
• Asthma 3%
• Proteins 3%

Chemical Compounds

• Insulin Derivative 50%
• Tyrosine 37%
• Polarization 36%
• Protein 20%