The Tools for Virulence of Cryptococcus neoformans

Carolina Coelho, Anamelia Lorenzetti Bocca, Arturo Casadevall

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths each year. It is believed that most humans are infected with C. neoformans, possibly in a form that survives through latency in the lung and can reactivate to cause disease if the host becomes immunosuppressed. C. neoformans has a remarkably sophisticated intracellular survival capacities yet it is a free-living fungus with no requirement for mammalian virulence whatsoever. In this review, we discuss the tools that C. neoformans possesses to achieve survival, latency and virulence within its host. Some of these tools are mechanisms to withstand starvation and others aim to protect against microbicidal molecules produced by the immune system. Furthermore, we discuss how these tools were acquired through evolutionary pressures and perhaps accidental stochastic events, all of which combined to produce an organism with an unusual and unique intracellular pathogenic strategy.

Original languageEnglish (US)
Title of host publicationAdvances in Applied Microbiology
PublisherAcademic Press Inc.
Pages1-41
Number of pages41
DOIs
StatePublished - 2014

Publication series

NameAdvances in Applied Microbiology
Volume87
ISSN (Print)0065-2164

Keywords

  • Amoeba-macrophage
  • Antimicrobial mechanisms
  • Capsule
  • Evolution
  • Fungal immunity
  • Pbl1
  • Trojan horse
  • Virulence factors

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

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  • Cite this

    Coelho, C., Bocca, A. L., & Casadevall, A. (2014). The Tools for Virulence of Cryptococcus neoformans. In Advances in Applied Microbiology (pp. 1-41). (Advances in Applied Microbiology; Vol. 87). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-800261-2.00001-3