The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes

Jose L. Ramirez, George Dimopoulos

Research output: Contribution to journalArticle


Dengue virus has become one of the most important arboviral pathogens affecting the world today. The virus is transmitted among humans by the mosquitoes Aedes aegypti and Ae. albopictus. Like other vector-borne pathogens, this virus encounters innate immune defenses within the mosquito vector that limit infection. We have previously demonstrated the involvement of the Toll pathway in the anti-dengue defense at 7 days after infection. In the present study, we have investigated the activity of this immune signaling pathway against different dengue virus serotypes at the early stages of infection in laboratory and field-derived mosquito strains. Our studies corroborate the importance of the Toll pathway in the anti-dengue defense repertoire at 3 days after an infectious blood meal, when new virions are released from the midgut for dissemination and infection of other mosquito tissues. These immune defenses are furthermore conserved among different Ae. aegypti strains and can act against a broad range of dengue virus serotypes.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalDevelopmental and Comparative Immunology
Issue number6
Publication statusPublished - Jun 2010



  • Arbovirus
  • Dengue
  • Innate immunity
  • Toll pathway

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

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