The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali

Boubacar Traore, Younoussou Koné, Safiatou Doumbo, Didier Doumtabé, Abdramane Traoré, Peter D. Crompton, Marko Mircetic, Chiung Yu Huang, Kassoum Kayentao, Alassane Dicko, Issaka Sagara, Ruth D. Ellis, Kazutoyo Miura, Agnes Guindo, Louis H. Miller, Ogobara K. Doumbo, Susan K. Pierce

Research output: Contribution to journalArticle

Abstract

Antibodies play a key role in controlling blood stage malaria infections, and an effective blood stage malaria vaccine will likely require that it induce vaccine-specific memory B cells (MBCs). Our previous studies showed that the addition of the TLR9 agonist CpG to Plasmodium falciparum protein subunit vaccines greatly increased their efficacy in inducing MBCs in nonimmune U.S. volunteers. Here we show that in contrast the same CpG-containing malaria vaccine did not enhance the acquisition of MBCs in semi-immune adults living in Mali. Understanding the molecular basis of this apparent refractoriness to TLR9 agonist will be of significant interest in vaccine design.

Original languageEnglish (US)
Pages (from-to)7299-7303
Number of pages5
JournalVaccine
Volume27
Issue number52
DOIs
StatePublished - Dec 9 2009

Keywords

  • Malaria
  • Memory B cells
  • Plasmodium falciparum
  • Toll-like receptor 9

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Traore, B., Koné, Y., Doumbo, S., Doumtabé, D., Traoré, A., Crompton, P. D., Mircetic, M., Huang, C. Y., Kayentao, K., Dicko, A., Sagara, I., Ellis, R. D., Miura, K., Guindo, A., Miller, L. H., Doumbo, O. K., & Pierce, S. K. (2009). The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali. Vaccine, 27(52), 7299-7303. https://doi.org/10.1016/j.vaccine.2009.08.023