The time is now for a new approach to primary ovarian insufficiency

Amber R. Cooper, Valerie Baker, Evelina W. Sterling, Mary E. Ryan, Teresa K. Woodruff, Lawrence M. Nelson

Research output: Contribution to journalArticle

Abstract

Objective: To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause or premature ovarian failure, is defined by the presence of menopausal-level serum gonadotropins in association with irregular menses in adolescent girls or women younger than 40 years. It can be iatrogenic as related to cancer therapy or may arise spontaneously, either alone or as part of a host of ultrarare syndromes. In a large percentage of spontaneous cases no pathogenic mechanism can be identified. Design: Literature review and consensus building at a multidisciplinary scientific workshop. Conclusion(s): There are major gaps in knowledge regarding the etiologic mechanisms, psychosocial effects, natural history, and medical and psychosocial management of primary ovarian insufficiency. An international research consortium and disease registry formed under the guidance of an umbrella organization would provide a pathway to comprehensively increase basic and clinical knowledge about the condition. Such a consortium and patient registry also would provide clinical samples and clinical data with a goal toward defining the specific pathogenic mechanisms. An international collaborative approach that combines the structure of a patient registry with the principles of integrative care and community-based participatory research is needed to advance the field of primary ovarian insufficiency.

Original languageEnglish (US)
Pages (from-to)1890-1897
Number of pages8
JournalFertility and sterility
Volume95
Issue number6
DOIs
StatePublished - May 1 2011
Externally publishedYes

Fingerprint

Primary Ovarian Insufficiency
Registries
Premature Menopause
Community-Based Participatory Research
Menstruation
Second Primary Neoplasms
Natural History
Gonadotropins
Organizations
Education
Serum
Research

Keywords

  • diminished ovarian reserve
  • infertility
  • integrative medicine
  • menstrual cycle
  • participatory research
  • patient registry
  • premature menopause
  • premature ovarian failure (POF)
  • Primary ovarian insufficiency (POI)
  • research consortia
  • sex steroid deficiency

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Cooper, A. R., Baker, V., Sterling, E. W., Ryan, M. E., Woodruff, T. K., & Nelson, L. M. (2011). The time is now for a new approach to primary ovarian insufficiency. Fertility and sterility, 95(6), 1890-1897. https://doi.org/10.1016/j.fertnstert.2010.01.016

The time is now for a new approach to primary ovarian insufficiency. / Cooper, Amber R.; Baker, Valerie; Sterling, Evelina W.; Ryan, Mary E.; Woodruff, Teresa K.; Nelson, Lawrence M.

In: Fertility and sterility, Vol. 95, No. 6, 01.05.2011, p. 1890-1897.

Research output: Contribution to journalArticle

Cooper, AR, Baker, V, Sterling, EW, Ryan, ME, Woodruff, TK & Nelson, LM 2011, 'The time is now for a new approach to primary ovarian insufficiency', Fertility and sterility, vol. 95, no. 6, pp. 1890-1897. https://doi.org/10.1016/j.fertnstert.2010.01.016
Cooper, Amber R. ; Baker, Valerie ; Sterling, Evelina W. ; Ryan, Mary E. ; Woodruff, Teresa K. ; Nelson, Lawrence M. / The time is now for a new approach to primary ovarian insufficiency. In: Fertility and sterility. 2011 ; Vol. 95, No. 6. pp. 1890-1897.
@article{a6248ff009a9496494efffde76acf64b,
title = "The time is now for a new approach to primary ovarian insufficiency",
abstract = "Objective: To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause or premature ovarian failure, is defined by the presence of menopausal-level serum gonadotropins in association with irregular menses in adolescent girls or women younger than 40 years. It can be iatrogenic as related to cancer therapy or may arise spontaneously, either alone or as part of a host of ultrarare syndromes. In a large percentage of spontaneous cases no pathogenic mechanism can be identified. Design: Literature review and consensus building at a multidisciplinary scientific workshop. Conclusion(s): There are major gaps in knowledge regarding the etiologic mechanisms, psychosocial effects, natural history, and medical and psychosocial management of primary ovarian insufficiency. An international research consortium and disease registry formed under the guidance of an umbrella organization would provide a pathway to comprehensively increase basic and clinical knowledge about the condition. Such a consortium and patient registry also would provide clinical samples and clinical data with a goal toward defining the specific pathogenic mechanisms. An international collaborative approach that combines the structure of a patient registry with the principles of integrative care and community-based participatory research is needed to advance the field of primary ovarian insufficiency.",
keywords = "diminished ovarian reserve, infertility, integrative medicine, menstrual cycle, participatory research, patient registry, premature menopause, premature ovarian failure (POF), Primary ovarian insufficiency (POI), research consortia, sex steroid deficiency",
author = "Cooper, {Amber R.} and Valerie Baker and Sterling, {Evelina W.} and Ryan, {Mary E.} and Woodruff, {Teresa K.} and Nelson, {Lawrence M.}",
year = "2011",
month = "5",
day = "1",
doi = "10.1016/j.fertnstert.2010.01.016",
language = "English (US)",
volume = "95",
pages = "1890--1897",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The time is now for a new approach to primary ovarian insufficiency

AU - Cooper, Amber R.

AU - Baker, Valerie

AU - Sterling, Evelina W.

AU - Ryan, Mary E.

AU - Woodruff, Teresa K.

AU - Nelson, Lawrence M.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Objective: To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause or premature ovarian failure, is defined by the presence of menopausal-level serum gonadotropins in association with irregular menses in adolescent girls or women younger than 40 years. It can be iatrogenic as related to cancer therapy or may arise spontaneously, either alone or as part of a host of ultrarare syndromes. In a large percentage of spontaneous cases no pathogenic mechanism can be identified. Design: Literature review and consensus building at a multidisciplinary scientific workshop. Conclusion(s): There are major gaps in knowledge regarding the etiologic mechanisms, psychosocial effects, natural history, and medical and psychosocial management of primary ovarian insufficiency. An international research consortium and disease registry formed under the guidance of an umbrella organization would provide a pathway to comprehensively increase basic and clinical knowledge about the condition. Such a consortium and patient registry also would provide clinical samples and clinical data with a goal toward defining the specific pathogenic mechanisms. An international collaborative approach that combines the structure of a patient registry with the principles of integrative care and community-based participatory research is needed to advance the field of primary ovarian insufficiency.

AB - Objective: To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause or premature ovarian failure, is defined by the presence of menopausal-level serum gonadotropins in association with irregular menses in adolescent girls or women younger than 40 years. It can be iatrogenic as related to cancer therapy or may arise spontaneously, either alone or as part of a host of ultrarare syndromes. In a large percentage of spontaneous cases no pathogenic mechanism can be identified. Design: Literature review and consensus building at a multidisciplinary scientific workshop. Conclusion(s): There are major gaps in knowledge regarding the etiologic mechanisms, psychosocial effects, natural history, and medical and psychosocial management of primary ovarian insufficiency. An international research consortium and disease registry formed under the guidance of an umbrella organization would provide a pathway to comprehensively increase basic and clinical knowledge about the condition. Such a consortium and patient registry also would provide clinical samples and clinical data with a goal toward defining the specific pathogenic mechanisms. An international collaborative approach that combines the structure of a patient registry with the principles of integrative care and community-based participatory research is needed to advance the field of primary ovarian insufficiency.

KW - diminished ovarian reserve

KW - infertility

KW - integrative medicine

KW - menstrual cycle

KW - participatory research

KW - patient registry

KW - premature menopause

KW - premature ovarian failure (POF)

KW - Primary ovarian insufficiency (POI)

KW - research consortia

KW - sex steroid deficiency

UR - http://www.scopus.com/inward/record.url?scp=79955015724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955015724&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2010.01.016

DO - 10.1016/j.fertnstert.2010.01.016

M3 - Article

VL - 95

SP - 1890

EP - 1897

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -