TY - JOUR
T1 - The TestSmart-HPV program - Development of an integrated approach for testing high production volume chemicals
AU - Green, Sidney
AU - Goldberg, Alan M.
AU - Zurlo, Joanne
N1 - Funding Information:
In 1998, the Environmental Protection Agency (EPA) and the Chemical Manufacturers Association (CMA), and the Environmental Defense Fund developed a framework for the High Production Volume Chemical Challenge. This initiative was prompted by separate studies by each organization that indicated substantial inadequacies in the amount of basic toxicity data now available for chemicals produced in high volumes (more than one million pounds annually). Under the Challenge, producers of about 2800 high-volume chemicals have been invited to make a voluntary commitment to fill gaps in basic data on their chemicals—using an internationally agreed-upon template known as the Screening Information Data Set (SIDS)—within the next 5 years.
PY - 2001/4
Y1 - 2001/4
N2 - The TestSmart program was developed in response to the High Production Volume Chemical Challenge, a voluntary initiative under which chemical producers provide basic toxicity data on chemicals produced in greater than one million pounds annually. Specifically, under the Challenge, chemical producers will generate data as needed to complete the Screening Information Data Set (SIDS), as defined by the Organization for Economic Cooperation and Development (OECD). The TestSmart program is a collaborative effort of the Johns Hopkins Center for Alternatives to Animal Testing, the Environmental Defense Fund, Carnegie-Mellon University, and the University of Pittsburgh. The goal of the TestSmart program is to provide a humane and efficient approach to collecting SIDS data. The program has two objectives, one immediate and the other more long term. The immediate objective has been to make recommendations to reduce the number of animals used in collecting SIDS data under the Challenge. This was accomplished, through a group process, by examining the current status of alternative methods for SIDS end-points and by providing an assessment of the "state of readiness" of current and potential future alternatives. The long-term objective is to provide a model for other programs to follow the TestSmart concept of a more efficient and humane approach to obtain toxicological data of interest to regulators and the public.
AB - The TestSmart program was developed in response to the High Production Volume Chemical Challenge, a voluntary initiative under which chemical producers provide basic toxicity data on chemicals produced in greater than one million pounds annually. Specifically, under the Challenge, chemical producers will generate data as needed to complete the Screening Information Data Set (SIDS), as defined by the Organization for Economic Cooperation and Development (OECD). The TestSmart program is a collaborative effort of the Johns Hopkins Center for Alternatives to Animal Testing, the Environmental Defense Fund, Carnegie-Mellon University, and the University of Pittsburgh. The goal of the TestSmart program is to provide a humane and efficient approach to collecting SIDS data. The program has two objectives, one immediate and the other more long term. The immediate objective has been to make recommendations to reduce the number of animals used in collecting SIDS data under the Challenge. This was accomplished, through a group process, by examining the current status of alternative methods for SIDS end-points and by providing an assessment of the "state of readiness" of current and potential future alternatives. The long-term objective is to provide a model for other programs to follow the TestSmart concept of a more efficient and humane approach to obtain toxicological data of interest to regulators and the public.
KW - Alternatives
KW - High production volume
KW - Screening information data set
KW - TestSmart
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U2 - 10.1006/rtph.2000.1435
DO - 10.1006/rtph.2000.1435
M3 - Article
C2 - 11350193
AN - SCOPUS:0034998439
VL - 33
SP - 105
EP - 109
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
SN - 0273-2300
IS - 2
ER -