The telomere-telomerase axis and the heart

Jan Kajstura, Marcello Rota, Konrad Urbanek, Toru Hosoda, Claudia Bearzi, Piero Anversa, Roberto Bolli, Annarosa Leri

Research output: Contribution to journalArticle

Abstract

The preservation of myocyte number and cardiac mass throughout life is dependent on the balance between cell death and cell division. Rapidly emerging evidence indicates that new myocytes can be formed through the activation and differentiation of resident cardiac progenitor cells. The critical issue is the identification of mechanisms that define the aging of cardiac progenitor cells and, ultimately, their inability to replace dying myocytes. The most reliable marker of cellular senescence is the modification of the telomere-telomerase axis, together with the expression of the cell cycle inhibitors p16 INK4a and p53. Cellular senescence is characterized by biochemical events that occur within the cell. In this regard, one of the most relevant processes is represented by repeated oxidative stress that may evolve into the activation of the cell death program or result in the development of a senescent phenotype. Thus, the modulation of telomerase activity and the control of telomeric length, together with the attenuation of the formation of reactive oxygen species, may represent important therapeutic tools in regenerative medicine and in prevention of aging and diabetic cardiomyopathies.

Original languageEnglish (US)
Pages (from-to)2125-2141
Number of pages17
JournalAntioxidants and Redox Signaling
Volume8
Issue number11-12
StatePublished - Nov 2006
Externally publishedYes

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Cell Aging
Telomerase
Telomere
Cell death
Muscle Cells
Cell Death
Stem Cells
Aging of materials
Chemical activation
Cells
Diabetic Cardiomyopathies
Regenerative Medicine
Oxidative stress
Cardiac Myocytes
Cell Division
Reactive Oxygen Species
Cell Cycle
Oxidative Stress
Modulation
Phenotype

ASJC Scopus subject areas

  • Biochemistry

Cite this

Kajstura, J., Rota, M., Urbanek, K., Hosoda, T., Bearzi, C., Anversa, P., ... Leri, A. (2006). The telomere-telomerase axis and the heart. Antioxidants and Redox Signaling, 8(11-12), 2125-2141.

The telomere-telomerase axis and the heart. / Kajstura, Jan; Rota, Marcello; Urbanek, Konrad; Hosoda, Toru; Bearzi, Claudia; Anversa, Piero; Bolli, Roberto; Leri, Annarosa.

In: Antioxidants and Redox Signaling, Vol. 8, No. 11-12, 11.2006, p. 2125-2141.

Research output: Contribution to journalArticle

Kajstura, J, Rota, M, Urbanek, K, Hosoda, T, Bearzi, C, Anversa, P, Bolli, R & Leri, A 2006, 'The telomere-telomerase axis and the heart', Antioxidants and Redox Signaling, vol. 8, no. 11-12, pp. 2125-2141.
Kajstura J, Rota M, Urbanek K, Hosoda T, Bearzi C, Anversa P et al. The telomere-telomerase axis and the heart. Antioxidants and Redox Signaling. 2006 Nov;8(11-12):2125-2141.
Kajstura, Jan ; Rota, Marcello ; Urbanek, Konrad ; Hosoda, Toru ; Bearzi, Claudia ; Anversa, Piero ; Bolli, Roberto ; Leri, Annarosa. / The telomere-telomerase axis and the heart. In: Antioxidants and Redox Signaling. 2006 ; Vol. 8, No. 11-12. pp. 2125-2141.
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