The Tail of Mycolic Acids

Jeff Zhiqiang Lu, Sean T. Prigge

Research output: Contribution to journalShort surveypeer-review

Abstract

The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel.

Original languageEnglish (US)
Pages (from-to)309-310
Number of pages2
JournalChemistry and Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 21 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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