The Tail of Mycolic Acids

Jeff Zhiqiang Lu, Sean Taylor Prigge

Research output: Contribution to journalArticle

Abstract

The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel.

Original languageEnglish (US)
Pages (from-to)309-310
Number of pages2
JournalChemistry and Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 21 2008

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Mycolic Acids
X Ray Crystallography
Tunnels
Tuberculosis
X ray crystallography
Substrates
Enzymes

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

The Tail of Mycolic Acids. / Lu, Jeff Zhiqiang; Prigge, Sean Taylor.

In: Chemistry and Biology, Vol. 15, No. 4, 21.04.2008, p. 309-310.

Research output: Contribution to journalArticle

Lu, Jeff Zhiqiang ; Prigge, Sean Taylor. / The Tail of Mycolic Acids. In: Chemistry and Biology. 2008 ; Vol. 15, No. 4. pp. 309-310.
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