The t(10;11)(p12;q23) translocation in acute leukaemia: A cytogenetic and clinical study of 20 patients

D. M. Lillington; B. D. Young; R. Berger; M. Martineau; A. V. Moorman; L. M. Seeker-Walker

doi:10.1038/sj.leu.2401015

The t(10;11)(p12;q23) translocation in acute leukaemia: A cytogenetic and clinical study of 20 patients

D. M. Lillington, B. D. Young, R. Berger, M. Martineau, A. V. Moorman, L. M. Seeker-Walker

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.

Original language	English (US)
Pages (from-to)	801-804
Number of pages	4
Journal	Leukemia
Volume	12
Issue number	5
DOIs	https://doi.org/10.1038/sj.leu.2401015
State	Published - 1998
Externally published	Yes

Keywords

11q23
AF10
Acute lymphoblastic leukemia
Acute myeloid leukemia
MLL
t(10;11)

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/sj.leu.2401015

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abstract = "The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.",

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AU - Lillington, D. M.

AU - Young, B. D.

AU - Berger, R.

AU - Martineau, M.

AU - Moorman, A. V.

AU - Seeker-Walker, L. M.

PY - 1998

Y1 - 1998

N2 - The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.

AB - The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.

KW - 11q23

KW - AF10

KW - Acute lymphoblastic leukemia

KW - Acute myeloid leukemia

KW - MLL

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The t(10;11)(p12;q23) translocation in acute leukaemia: A cytogenetic and clinical study of 20 patients

Abstract

Keywords

ASJC Scopus subject areas

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