The t(10;11)(p12;q23) translocation in acute leukaemia: A cytogenetic and clinical study of 20 patients

D. M. Lillington, B. D. Young, R. Berger, M. Martineau, A. V. Moorman, L. M. Seeker-Walker

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.

Original languageEnglish (US)
Pages (from-to)801-804
Number of pages4
JournalLeukemia
Volume12
Issue number5
DOIs
StatePublished - 1998

Keywords

  • 11q23
  • AF10
  • Acute lymphoblastic leukemia
  • Acute myeloid leukemia
  • MLL
  • t(10;11)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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