TY - JOUR
T1 - The T cell as a bridge between innate and adaptive immune systems
T2 - Implications for the kidney
AU - Rabb, Hamid
N1 - Funding Information:
This work was supported by NIH R01 DK54770 and NKF Clinical Scientist Award. The author is indebted to Drs. Joseph Handler, Chris Lu and John Hotchkiss and for helpful suggestions during manuscript preparation, Ms. Vanessa Schlinger and Dr. Melissa Burne with tables and figures, and Ms. Jan Lovick with references. Reproduction of Figures 1 , 2 , 3 and 4 in color was made possible by Texas Biotech Corp., Houston, Texas.
PY - 2002
Y1 - 2002
N2 - The immune system is classically divided into innate and adaptive components with distinct roles and functions. T cells are major components of the adaptive immune system. T cells are firmly established to mediate various immune-mediated kidney diseases and are current targets for therapy. Ischemic acute renal failure, a major cause of native kidney and allograft dysfunction, is mediated in part by inflammatory components of the innate immune system. However, recent data from experimental models in kidney as well as liver, intestine, brain and heart implicate T cells as important mediators of ischemia reperfusion injury. These data reveal new insights into the pathogenesis of ischemic acute renal failure, as well as identify novel and feasible therapeutic approaches. Furthermore, the identification of T cells as a mediator of early alloantigen-independent tissue injury demonstrates that the functional capacity of T cells spreads beyond adaptive immunity into the realm of the innate immune response.
AB - The immune system is classically divided into innate and adaptive components with distinct roles and functions. T cells are major components of the adaptive immune system. T cells are firmly established to mediate various immune-mediated kidney diseases and are current targets for therapy. Ischemic acute renal failure, a major cause of native kidney and allograft dysfunction, is mediated in part by inflammatory components of the innate immune system. However, recent data from experimental models in kidney as well as liver, intestine, brain and heart implicate T cells as important mediators of ischemia reperfusion injury. These data reveal new insights into the pathogenesis of ischemic acute renal failure, as well as identify novel and feasible therapeutic approaches. Furthermore, the identification of T cells as a mediator of early alloantigen-independent tissue injury demonstrates that the functional capacity of T cells spreads beyond adaptive immunity into the realm of the innate immune response.
KW - Acute renal failure
KW - Adaptive immunity
KW - Innate immunity
KW - Ischemia reperfusion
KW - T cell
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U2 - 10.1046/j.1523-1755.2002.00378.x
DO - 10.1046/j.1523-1755.2002.00378.x
M3 - Article
C2 - 12028434
AN - SCOPUS:0036098822
SN - 0085-2538
VL - 61
SP - 1935
EP - 1946
JO - Kidney international
JF - Kidney international
IS - 6
ER -