The systems biology of glycosylation

Michael P. Murrell, Kevin J. Yarema, Andre Levchenko

Research output: Contribution to journalReview articlepeer-review

Abstract

Glycosylation can have a profound influence on the function of a variety of eukaryotic cells. In particular, it can affect signal transduction and cell-cell communication properties and thus shape critical cell decisions, including the regulation of differentiation and apoptosis. Regulation of glycosylation has multiple layers of complexity, both structural and functional, which make its experimental and theoretical analysis difficult to perform and interpret. Novel research methodologies provided by systems biology can help to address many outstanding issues and integrate glycosylation with other metabolic and cell regulation processes. Here we review the toolbox available for biochemical systems analysis of glycosylation.

Original languageEnglish (US)
Pages (from-to)1334-1347
Number of pages14
JournalChemBioChem
Volume5
Issue number10
DOIs
StatePublished - Oct 4 2004

Keywords

  • Biochemical pathways
  • Carbohydrates
  • Glycosylation
  • Metabolic flux
  • Systems biology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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