The systemic lupus erythematosus tri-nation study: Longitudinal changes in physical and mental well-being

P. Panopalis, M. Petri, S. Manzi, D. A. Isenberg, C. Gordon, J. L. Senecal, J. R. Penrod, L. Joseph, Y. St. Pierre, C. Pineau, P. R. Fortin, N. Sutcliffe, J. R. Goulet, D. Choquette, T. Grodzicky, J. M. Esdaile, Ann E. Clarke, Tina Panaritis, Popi Panaritis, Kathy MargonisMauro Trifero, Diane Ferland, Carolyn Neville, Mary Orsini-Dudin, Joan Rairie, Stephanie Heaton

Research output: Contribution to journalArticlepeer-review


Objective. We have shown that SLE patients in Canada and the UK incurred 20% and 13% lower health costs than those in the US, respectively, but did not experience worse outcomes as expressed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. We now compare change in quality of life in these patients. Patients and methods. Seven hundred and fifteen SLE patients (Canada 231, US 269, UK 215) completed the SF-36 annually over four years. The annual change in the SF-36 Physical and Mental Component Summary (PCS and MCS) scores over the course of the study were summarized by estimating a linear trend for each individual patient using hierarchical modelling. Cross-country comparison of the slopes in the PCS and MCS scores was then performed using simultaneous regressions. Results. The estimated mean annual changes (95% credible interval [CrI]) in the PCS scores in Canada, the US, and the UK were 0.18 (-0.07, 0.43), -0.05 (-0.27, 0.17), and 0.03 (-0.20, 0.27), respectively; the mean annual changes in the MCS scores were 0.15 (-0.04, 0.34), 0.23 (0.09, 0.37), and 0.08 (-0.10, 0.27), respectively. Regression results showed that the mean annual changes in PCS and MCS scores did not substantially differ across countries. Conclusion. Quality of life remained stable across countries. Despite Canadian and British patients incurring lower health costs, on average, patients experienced similar changes in physical and mental well-being.

Original languageEnglish (US)
Pages (from-to)751-755
Number of pages5
Issue number6
StatePublished - Jun 2005
Externally publishedYes


  • Direct healthcare costs
  • Disease damage
  • Health status
  • Quality of life
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)


Dive into the research topics of 'The systemic lupus erythematosus tri-nation study: Longitudinal changes in physical and mental well-being'. Together they form a unique fingerprint.

Cite this