The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

L. Zhao, L. Qiao, S. B. Rong, A. P. Kozikowski

Research output: Contribution to journalArticle

Abstract

The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)8711-8715
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number45
DOIs
StatePublished - Nov 4 2000

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators'. Together they form a unique fingerprint.

  • Cite this