The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

L. Zhao, L. Qiao, S. B. Rong, A. P. Kozikowski

Research output: Contribution to journalArticlepeer-review


The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)8711-8715
Number of pages5
JournalTetrahedron Letters
Issue number45
StatePublished - Nov 4 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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