Abstract
As part of our program to develop PET tracers for the 5-HT reuptake site, venlafaxine, a non-classical, fast-acting antidepressant, was selected as a candidate for labelling with 11C for in vivo evaluation. [O-methyl-11C]venlafaxine was produced by the alkylation of O-desmethyl venlafaxine with [11C]methyl iodide followed by HPLC purification and formulation. Radiochemically pure [O-methyl-11C]venlafaxine was obtained in a 30 ± 5 % decay corrected radiochemical yield and a specific activity > 50 GBq/μmol (1.4 Ci/μmol) at the end of synthesis. For a typical production starting with 46 GBq (1.3 Ci) [11C]CO2, 5.2 GBq (140 mCi) [O-methyl-11C]venlafaxine was obtained as a sterile, formulated solution in a synthesis time of 30 min (counted from EOB).
Original language | English (US) |
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Pages (from-to) | 89-95 |
Number of pages | 7 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 39 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1997 |
Externally published | Yes |
Keywords
- 5-HT reuptake
- C
- PET
- Venlafaxine
- antidepressants
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry