TY - JOUR
T1 - The synaptic vesicle cycle revisited
T2 - New insights into the modes and mechanisms
AU - Chanaday, Natali L.
AU - Cousin, Michael A.
AU - Milosevic, Ira
AU - Watanabe, Shigeki
AU - Morgan, Jennifer R.
N1 - Funding Information:
This work was supported by: Schram-Stiftung T287/25457 and Deutsche Forschungsgemeinschaft (Emmy NoetherYoungInvestigatorAwardMI-1702/1toI.M.);theWellcomeTrust(204954/Z/16/ZtoM.A.C.);theNational ScienceFoundation(1727260toS.W.),theNationalInstitutesofHealth(NINDSDP2NS111133andR01NS105810to S.W.); the McKnight Foundation (S.W.); the Sloan Foundation (S.W.); and the National Institutes of Health (NINDS/ NIAR01NS078165toJ.R.M.andNIMHR01MH066198toDr.EgeKavalali,whichsupportsN.L.C.).WethankDrago-mir Milovanovic for helpful comments on this manuscript. The authors declare no competing financial interests. Correspondence should be addressed to Jennifer R. Morgan at jmorgan@mbl.edu. https://doi.org/10.1523/JNEUROSCI.1158-19.2019 Copyright © 2019 the authors
Funding Information:
This work was supported by: Schram-Stiftung T287/25457 and Deutsche Forschungsgemeinschaft (Emmy Noether Young Investigator Award MI-1702/1 to I.M.); the Wellcome Trust (204954/Z/16/Z to M.A.C.); the National Science Foundation (1727260 to S.W.), the National Institutes of Health (NINDS DP2 NS111133 and R01 NS105810 to S.W.); the McKnight Foundation (S.W.); the Sloan Foundation (S.W.); and the National Institutes of Health (NINDS/ NIA R01 NS078165 to J.R.M. and NIMH R01 MH066198 to Dr. Ege Kavalali, which supports N.L.C.). We thank Dragomir Milovanovic for helpful comments on this manuscript.
Publisher Copyright:
©2019 the authors.
PY - 2019
Y1 - 2019
N2 - Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs) locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are recovered by either fusion pore closure (kiss-and-run) or clathrin-mediated endocytosis directly from the plasma membrane. However, recent data have revealed that SV formation is more complex than previously envisaged. For example, two additional recycling pathways have been discovered, ultrafast endocytosis and activity-dependent bulk endocytosis, in which SVs are regenerated from the internalized membrane and synaptic endosomes. Furthermore, these diverse modes of endocytosis appear to influence both the molecular composition and subsequent physiological role of individual SVs. In addition, previously unknown complexity in SV refilling and reclustering has been revealed. This review presents a modern view of the SV life cycle and discusses how neuronal subtype, physiological temperature, and individual activity patterns can recruit different endocytic modes to generate new SVs and sculpt subsequent presynaptic performance.
AB - Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs) locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are recovered by either fusion pore closure (kiss-and-run) or clathrin-mediated endocytosis directly from the plasma membrane. However, recent data have revealed that SV formation is more complex than previously envisaged. For example, two additional recycling pathways have been discovered, ultrafast endocytosis and activity-dependent bulk endocytosis, in which SVs are regenerated from the internalized membrane and synaptic endosomes. Furthermore, these diverse modes of endocytosis appear to influence both the molecular composition and subsequent physiological role of individual SVs. In addition, previously unknown complexity in SV refilling and reclustering has been revealed. This review presents a modern view of the SV life cycle and discusses how neuronal subtype, physiological temperature, and individual activity patterns can recruit different endocytic modes to generate new SVs and sculpt subsequent presynaptic performance.
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U2 - 10.1523/JNEUROSCI.1158-19.2019
DO - 10.1523/JNEUROSCI.1158-19.2019
M3 - Article
C2 - 31619489
AN - SCOPUS:85073459874
SN - 0270-6474
VL - 39
SP - 8209
EP - 8216
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 42
ER -