The surgical bed after BCNU polymer wafer placement for recurrent glioma

Serial assessment on CT and MR imaging

Dima A. Hammoud, Clifford J. Belden, Amy C. Ho, Gerald J. Dal Pan, Edward H. Herskovits, Dana C. Hilt, Henry Brem, Martin Gilbert Pomper

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. The objective of our study was to describe the CT and MR imaging appearances of the surgical bed in the brains of patients receiving biodegradable polymers impregnated with N, N1, 3-Bis-(2-chloroethyl)-N-nitrosourea (BCNU) for recurrent glioma and to determine whether patients receiving placebos could be differentiated from those receiving BCNU based on the pattern and growth kinetics of tumor recurrence. MATERIALS AND METHODS. The CT and MR images of 20 patients who underwent surgery for resection of recurrent high-grade gliomas and placement of intratumoral wafers (11 received BCNU polymer wafers, nine received control wafers) were analyzed for wafer appearance, volume of gas in the tumor bed, and volume of enhancement on serial scans. RESULTS. Wafers appeared as linear hyperdense structures on CT and as linear low-signal-intensity structures on MR imaging and caused no significant enhancement. In the BCNU polymer group, gas volume was 4.0 ± 3.4 cm3 (mean ± SD), whereas gas volume was 1.6 ± 3.0 cm3 for the placebo group (Mann-Whimey test, p = 0.03). A trend toward linear rather than exponential recurrent tumor growth was identified for the BCNU polymer group but not for the placebo group. CONCLUSION. BCNU polymer wafers have a specific appearance on CT and MR imaging with which radiologists should be familiar: gas in the surgical bed is an expected transient finding, and tumor regrowth in patients receiving BCNU polymer wafers appeared to occur at a slower rate than in those receiving the placebo.

Original languageEnglish (US)
Pages (from-to)1469-1475
Number of pages7
JournalAmerican Journal of Roentgenology
Volume180
Issue number5
StatePublished - May 1 2003

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Carmustine
Glioma
Polymers
Gases
Placebos
Neoplasms
Growth
Tumor Burden
Recurrence
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hammoud, D. A., Belden, C. J., Ho, A. C., Dal Pan, G. J., Herskovits, E. H., Hilt, D. C., ... Pomper, M. G. (2003). The surgical bed after BCNU polymer wafer placement for recurrent glioma: Serial assessment on CT and MR imaging. American Journal of Roentgenology, 180(5), 1469-1475.

The surgical bed after BCNU polymer wafer placement for recurrent glioma : Serial assessment on CT and MR imaging. / Hammoud, Dima A.; Belden, Clifford J.; Ho, Amy C.; Dal Pan, Gerald J.; Herskovits, Edward H.; Hilt, Dana C.; Brem, Henry; Pomper, Martin Gilbert.

In: American Journal of Roentgenology, Vol. 180, No. 5, 01.05.2003, p. 1469-1475.

Research output: Contribution to journalArticle

Hammoud, DA, Belden, CJ, Ho, AC, Dal Pan, GJ, Herskovits, EH, Hilt, DC, Brem, H & Pomper, MG 2003, 'The surgical bed after BCNU polymer wafer placement for recurrent glioma: Serial assessment on CT and MR imaging', American Journal of Roentgenology, vol. 180, no. 5, pp. 1469-1475.
Hammoud DA, Belden CJ, Ho AC, Dal Pan GJ, Herskovits EH, Hilt DC et al. The surgical bed after BCNU polymer wafer placement for recurrent glioma: Serial assessment on CT and MR imaging. American Journal of Roentgenology. 2003 May 1;180(5):1469-1475.
Hammoud, Dima A. ; Belden, Clifford J. ; Ho, Amy C. ; Dal Pan, Gerald J. ; Herskovits, Edward H. ; Hilt, Dana C. ; Brem, Henry ; Pomper, Martin Gilbert. / The surgical bed after BCNU polymer wafer placement for recurrent glioma : Serial assessment on CT and MR imaging. In: American Journal of Roentgenology. 2003 ; Vol. 180, No. 5. pp. 1469-1475.
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AU - Hammoud, Dima A.

AU - Belden, Clifford J.

AU - Ho, Amy C.

AU - Dal Pan, Gerald J.

AU - Herskovits, Edward H.

AU - Hilt, Dana C.

AU - Brem, Henry

AU - Pomper, Martin Gilbert

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