Abstract
Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1019-1025 |
| Number of pages | 7 |
| Journal | Pediatric Blood and Cancer |
| Volume | 56 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2011 |
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Keywords
- Childhood cancer
- Clinical trials
- Cooperative groups
- Ethics
- History
ASJC Scopus subject areas
- Hematology
- Oncology
- Pediatrics, Perinatology, and Child Health
Cite this
The successful integration of research and care : How pediatric oncology became the subspecialty in which research defines the standard of care. / Unguru, Yoram.
In: Pediatric Blood and Cancer, Vol. 56, No. 7, 01.07.2011, p. 1019-1025.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The successful integration of research and care
T2 - How pediatric oncology became the subspecialty in which research defines the standard of care
AU - Unguru, Yoram
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.
AB - Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.
KW - Childhood cancer
KW - Clinical trials
KW - Cooperative groups
KW - Ethics
KW - History
UR - http://www.scopus.com/inward/record.url?scp=79954517832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954517832&partnerID=8YFLogxK
U2 - 10.1002/pbc.22976
DO - 10.1002/pbc.22976
M3 - Review article
C2 - 21284077
AN - SCOPUS:79954517832
VL - 56
SP - 1019
EP - 1025
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 7
ER -