The successful integration of research and care: How pediatric oncology became the subspecialty in which research defines the standard of care

Research output: Contribution to journalReview article

Abstract

Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.

Original languageEnglish (US)
Pages (from-to)1019-1025
Number of pages7
JournalPediatric Blood and Cancer
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Standard of Care
Pediatrics
Hope
Research
Biomedical Research
Neoplasms
Patient Care
Leukemia
Parents
Research Personnel
Therapeutics

Keywords

  • Childhood cancer
  • Clinical trials
  • Cooperative groups
  • Ethics
  • History

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Pediatric oncology successfully embodies the integration of patient care with medical research. Several factors may explain this phenomenon. Specifically, the study of childhood leukemia provided scientists with principles by which they could approach other forms of cancer. Multicenter, cooperative group RCTs resulted in meaningful advances. Parents' often desperate hope for a cure, combined with clinician-investigators efforts to continually improve upon treatments resulted in important improvements in children's lives. Finally, the seemingly tolerant regulatory oversight of human subjects research in the early years of childhood cancer research paradoxically helped link research with care, thus solidifying this bond for years to come.",
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