The subnuclear distribution of 5-HT3 receptors in the human nucleus of the solitary tract and other structures of the caudal medulla

Donald C. Ohuoha, Michael B. Knable, Steven S. Wolf, Joel E. Kleinman, Thomas M. Hyde

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of 5-HT3 receptors was examined in the human medulla using [3H]LY278584, a highly selective 5-HT3 receptor antagonist. The highest density of 5-HT3 receptors was found in the substantia gelatinosus subnucleus of nucleus of the solitary tract (NTS) throughout its rostrocaudal extent, followed by the dorsal subnucleus, the area postrema (AP), the commissural sub nucleus, the medial subnucleus, and in an arc correspondingto the gelatinosus of the spinal trigeminal nucleus (nSp5). The distribution of 5-HT3 receptors in the brain may help explain some of the reported CNS activities of 5-HT3-selective drugs. The anti-emetic and antinociceptive activities of 5-HT3 antagonists may be mediated by receptors in sensory areas of the brainstem.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalBrain research
Volume637
Issue number1-2
DOIs
StatePublished - Feb 21 1994
Externally publishedYes

Keywords

  • Area postrema
  • Emesis
  • Human brainstem
  • Nucleus tractus solitarius
  • Serotonin receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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