The subnuclear distribution of 5-HT(1A) receptors in the human nucleus of the solitary tract and selected structures of the caudal medulla

Christopher F. Spurney, Donald C. Ohuoha, Angela M. Murray, Joel E. Kleinman, Thomas M. Hyde

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of 5-HT(1A) receptors in the subnuclei of the human caudal nucleus of solitary tract and adjacent structures in the dorsal vagal complex was studied using [3H]8-OH-DPAT, a highly selective 5-HT(1A) receptor agonist. The highest binding of the labeled ligand was found in the dorsal motor nucleus of the vagus, followed by the medial, intermediate, and subpostremal subnuclei of the nucleus of solitary tract. Previous animal studies suggest an important role for these structures in the regulation of visceral function, particularly for the gastrointestinal and cardiovascular systems. The results of this study suggest the possibility of an analogous role for 5-HT(1A) receptors in the regulation of these autonomic pathways in humans as well.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalMcGill Journal of Medicine
Volume3
Issue number2
StatePublished - Sep 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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