@article{084dfc5ffdab437890e27a431e925428,
title = "The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects",
abstract = "Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, certain subjective effects predict therapeutic and other desirable outcomes. Underlying neurobiological mechanisms are likely necessary but not sufficient to confer full and enduring beneficial effects. We propose that the subjective effects of psychedelics are necessary for their enduring beneficial effects and that these subjective effects account for the majority of their benefit.",
author = "Yaden, {David B.} and Griffiths, {Roland R.}",
note = "Funding Information: We thank Chris Letheby (University of Western Australia), Albert Garcia-Romeu (Johns Hopkins University School of Medicine), Brian D. Earp (Yale University), Derek E. Anderson (Boston University), and Chaz Firestone (Johns Hopkins University) for their helpful comments and suggestions. Support for Drs. D. Yaden and Griffiths through the Johns Hopkins Center for Psychedelic and Consciousness Research was provided by Tim Ferriss, Matt Mullenweg, Blake Mycoskie, Craig Nerenberg, and the Steven and Alexandra Cohen Foundation. Funding Information: Dr. Griffiths reports grants from the Riverstyx Foundation, a crowdsourced funding campaign organized by Tim Ferris, and National Institute on Drug Abuse (grant R01DA03889) for research support outside of submitted the work; personal fees from the Heffter Research Institute (HRI) to cover travel costs as member of the board of directors of HRI outside the submitted work; and is site principal investigator for a multisite trial of psilocybin-facilitated treatment of major depressive disorder, which is sponsored by the Usona Institute. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2021",
month = apr,
day = "9",
doi = "10.1021/acsptsci.0c00194",
language = "English (US)",
volume = "4",
pages = "568--572",
journal = "ACS Pharmacology and Translational Science",
issn = "2575-9108",
publisher = "American Chemical Society",
number = "2",
}