The structural effects of the Cys-S-S-Cys bridge exchange by the His-Cu(II)-His motif studied on natural peptides - A promising tool for natural compounds-based design

Justyna Brasuń, Marek Cebrat, Łukasz Jaremko, Mariusz Jaremko, Gregor Ilc, Olimpia Gładysz, Igor Zhukov

Research output: Contribution to journalArticle

Abstract

A replacement of both Cys residues by His in oxytocin (OXT) sequence allows for the formation of the stable complex with the {NH2, N Im, NIm(macrochelate)} binding mode at the physiological pH. The detailed potentiometric and spectroscopic studies on the Cu(II) complexes of [His1,6]OXT, together with high resolution NMR investigations on 3D structures of Cu(II) complexes with [His1,6]OXT and [His1,6]AVP analogues are presented and discussed. Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S-S bridged AVP and OXT at pH values corresponding to the physiological pH.

Original languageEnglish (US)
Pages (from-to)4853-4857
Number of pages5
JournalDalton Transactions
Issue number25
DOIs
StatePublished - 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Inorganic Chemistry

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