The stress and strain of cytokinesis

Elizabeth M. Reichl, Janet C. Effler, Douglas N. Robinson

Research output: Contribution to journalReview article

Abstract

The ultimate goal of all signaling pathways in cytokinesis is to control the mechanical separation of the mother cell into two daughter cells. Because of the intrinsic mechanical nature of cytokinesis, it is essential to understand fully how cell shapes and the material properties of the cell are generated, how these shapes and material properties create force, and how motor proteins such as myosin-II modify the system to achieve successful cytokinesis. In this review (which is part of the Cytokinesis series), we discuss the relevant physical properties of cells, how these properties are measured and the basic models that are used to understand cell mechanics. Finally, we present our current understanding of how cytokinesis mechanics work.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalTrends in Cell Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 2005

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ASJC Scopus subject areas

  • Cell Biology

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