The strategic use of antiretrovirals to prevent HIV infection: A converging agenda

Rachel Baggaley, Meg Caroline Doherty, Andrew Ball, Nathan Ford, Gottfried Hirnschall

Research output: Contribution to journalArticle

Abstract

There is a clear convergence toward an overarching strategic use of antiretroviral drugs to prevent human immunodeficiency virus (HIV) infection. Four interventions-immediate antiretroviral therapy (ART) for the infected partner in a serodiscordant couple, preexposure prophylaxis (PrEP), prevention of mother-to-child transmission (PMTCT), and postexposure prophylaxis (PEP)-are all strongly recommended by the World Health Organization as effective ways to prevent HIV infection. For HIV-infected individuals, ART to protect an HIV-uninfected partner and PMTCT are both part of an expanding list of recommendations for starting ART immediately to both treat and prevent HIV infection. For HIV-uninfected individuals, PrEP and PEP are increasingly being seen as related interventions, and there are compelling reasons to consider the provision of PEP as a potential gateway to PrEP. The effectiveness of each of these interventions depends on overcoming barriers to seeking services, adequate community understanding and engagement, high levels of access and uptake of services including HIV testing and counselling, and high levels of adherence.

Original languageEnglish (US)
Pages (from-to)S159-S160
JournalClinical Infectious Diseases
Volume60
DOIs
StatePublished - 2015
Externally publishedYes

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Virus Diseases
HIV
Mothers
Counseling
Therapeutics
Pharmaceutical Preparations

Keywords

  • Antiretroviral therapy
  • HIV/AIDS
  • PMTCT
  • Postexposure prophylaxis
  • Preexposure prophylaxis

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

The strategic use of antiretrovirals to prevent HIV infection : A converging agenda. / Baggaley, Rachel; Doherty, Meg Caroline; Ball, Andrew; Ford, Nathan; Hirnschall, Gottfried.

In: Clinical Infectious Diseases, Vol. 60, 2015, p. S159-S160.

Research output: Contribution to journalArticle

Baggaley, Rachel ; Doherty, Meg Caroline ; Ball, Andrew ; Ford, Nathan ; Hirnschall, Gottfried. / The strategic use of antiretrovirals to prevent HIV infection : A converging agenda. In: Clinical Infectious Diseases. 2015 ; Vol. 60. pp. S159-S160.
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