The storage of norepinephrine and some of its derivatives in brain synaptosomes

Solomon H. Snyder; Jacques Glowinski; Julius Axelrod

doi:10.1016/0024-3205(65)90312-7

The storage of norepinephrine and some of its derivatives in brain synaptosomes

Solomon H. Snyder, Jacques Glowinski, Julius Axelrod

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19 Scopus citations

Abstract

The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.

Original language	English (US)
Pages (from-to)	797-807
Number of pages	11
Journal	Life Sciences
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(65)90312-7
State	Published - Apr 1965
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(65)90312-7

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abstract = "The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.",

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AU - Glowinski, Jacques

AU - Axelrod, Julius

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Y1 - 1965/4

N2 - The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.

AB - The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.

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The storage of norepinephrine and some of its derivatives in brain synaptosomes

Abstract

ASJC Scopus subject areas

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