The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)