The storage of norepinephrine and some of its derivatives in brain synaptosomes

Solomon H. Snyder, Jacques Glowinski, Julius Axelrod

Research output: Contribution to journalArticlepeer-review

Abstract

The subcellular localization of norepinephrine and some of its derivatives was determined in the rat brain after their intraventricular administration. The catecholamine derivatives, norepinephrine, epinephrine and dopamine, were highly localized in the synoptosomal fraction. The methoxyamine metabolites were also localized in synaptosomes but to a lesser extent. Octopamine, the β-hydroxylated metabolite of tyramine was more highly concentrated by the synaptosomal fraction than tyramine itself.

Original languageEnglish (US)
Pages (from-to)797-807
Number of pages11
JournalLife Sciences
Volume4
Issue number7
DOIs
StatePublished - Apr 1965
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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