The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.

N. B. Pandey, W. F. Marzluff

Research output: Contribution to journalArticlepeer-review

Abstract

Chimeric genes were made by fusing mouse histone genes with a human alpha-globin gene. The genes were introduced into mouse L cells and the stability of the chimeric mRNAs was measured when DNA synthesis was inhibited. An mRNA containing all the globin coding sequences and the last 30 nucleotides of the histone mRNA was degraded at the same rate as histone mRNA.

Original languageEnglish (US)
Pages (from-to)4557-4559
Number of pages3
JournalMolecular and cellular biology
Volume7
Issue number12
DOIs
StatePublished - Dec 1987
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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