The stem cell niche: Theme and variations

Benjamin Ohlstein, Toshie Kai, Eva Decotto, Allan Spradling

Research output: Contribution to journalArticle

Abstract

Stem cells in animal tissues are often located and controlled by special tissue microenvironments known as niches. Studies of stem cell niches in model systems such as Drosophila have revealed adhesive interactions, cell cycle modifications and intercellular signals that operate to control stem cell behavior. Candidate niches and regulatory molecules have also been identified in many mammalian tissues, including bone marrow, skin, gut and brain. While niches are an ancient evolutionary device with conserved features across diverse organisms, we suggest that certain niches display important differences in their organization and function.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume16
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

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Stem Cell Niche
Stem Cells
Adhesives
Drosophila
Cell Cycle
Bone Marrow
Equipment and Supplies
Skin
Brain

ASJC Scopus subject areas

  • Cell Biology

Cite this

Ohlstein, B., Kai, T., Decotto, E., & Spradling, A. (2004). The stem cell niche: Theme and variations. Current Opinion in Cell Biology, 16(6), 693-699. https://doi.org/10.1016/j.ceb.2004.09.003

The stem cell niche : Theme and variations. / Ohlstein, Benjamin; Kai, Toshie; Decotto, Eva; Spradling, Allan.

In: Current Opinion in Cell Biology, Vol. 16, No. 6, 12.2004, p. 693-699.

Research output: Contribution to journalArticle

Ohlstein, B, Kai, T, Decotto, E & Spradling, A 2004, 'The stem cell niche: Theme and variations', Current Opinion in Cell Biology, vol. 16, no. 6, pp. 693-699. https://doi.org/10.1016/j.ceb.2004.09.003
Ohlstein, Benjamin ; Kai, Toshie ; Decotto, Eva ; Spradling, Allan. / The stem cell niche : Theme and variations. In: Current Opinion in Cell Biology. 2004 ; Vol. 16, No. 6. pp. 693-699.
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