TY - JOUR
T1 - The spectrum of cholera in rural east pakistan. I. Correlation of bacteriologic and serologic results
AU - Woodward, William E.
AU - Mosley, Wiley H.
AU - McCormack, William M.
N1 - Funding Information:
The Pakistan-SEATO Cholera Research Laboratory is a part of the SEATO Cholera Research Program and is supported by the Ll.S. Agency for International Development, Department of State; the National Institutes of Health and the National Communicable Disease Center of the U.S. Department of Health, Education, and Welfare; and by the governments of Pakistan, the United Kingdom, and other SEATO nations. The NIH Cholera Advisory Committee coordinates the research program. These studies were supported in part by research agreement no. 196802 between the National Institutes of Health, Bethesda, Maryland, and the PakistanSEATO Cholera Research Laboratory, Dacca, East Pakistan. The contributions of Dr. K. A. Al-Mahmud, Mr. K. M. A. Aziz, Mr. Sukha Ranjan Paul, and the Serology and Bacteriology Branches are gratefully acknowledged. * Epidemic Intelligence Service Officer, NCDC, assigned to Epidemiology Division, Pakistan-SEATO Cholera Research Laboratory. t Formerly Epidemic Intelligence Service Officer, NCDC, assigned to Epidemiology Division, PakistanSEATO Cholera Research Laboratory. Please address requests for reprints to Dr. William E. Woodward, Pakistan-SEATO Cholera Research Laboratory, G.P.O. Box 128, Dacca, East Pakistan.
PY - 1970/5
Y1 - 1970/5
N2 - A group of 107 children was studied intensely throughout the course of a large epidemic of cholera in 1 village of East Pakistan. The overall rate of infection was 18.7%, and infection rates decreased with increasing age. The ratio of nonhospitalized to hospitalized infections was 5: 1. The percentage of detectable titers of vibriocidal antibody in blood specimens obtained before the epidemic increased markedly with age, while that of toxin-neutralization antibody titers declined slightly. Detectable, initial vibriocidal titers were associated with a lower rate of infection than were undetectable titers. The situation was reversed with regard to toxin-neutralization levels, although the presence of detectable titers tended to be associated with milder disease. All 20 infections were discovered by daily rectal swab cultures, while a 4-fold increase in vibriocidal titer was present in only 12 of these individuals, and an absolute rise of 20 or more antitoxin units/ml was present in 10. The duration of excretion of vibrios was significantly less in individuals who did not convert serologically.
AB - A group of 107 children was studied intensely throughout the course of a large epidemic of cholera in 1 village of East Pakistan. The overall rate of infection was 18.7%, and infection rates decreased with increasing age. The ratio of nonhospitalized to hospitalized infections was 5: 1. The percentage of detectable titers of vibriocidal antibody in blood specimens obtained before the epidemic increased markedly with age, while that of toxin-neutralization antibody titers declined slightly. Detectable, initial vibriocidal titers were associated with a lower rate of infection than were undetectable titers. The situation was reversed with regard to toxin-neutralization levels, although the presence of detectable titers tended to be associated with milder disease. All 20 infections were discovered by daily rectal swab cultures, while a 4-fold increase in vibriocidal titer was present in only 12 of these individuals, and an absolute rise of 20 or more antitoxin units/ml was present in 10. The duration of excretion of vibrios was significantly less in individuals who did not convert serologically.
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U2 - 10.1093/infdis/121.Supplement.S10
DO - 10.1093/infdis/121.Supplement.S10
M3 - Article
C2 - 4912066
AN - SCOPUS:84876785907
VL - 121
SP - S10-S16
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
ER -