The sorozoite, the merozoite, and the infected red cell: Parasite ligands and host receptors

Chetan E. Chitnis, Photini Sinnis, Louis H. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter


In this review, we discuss what is known about the receptors and ligands involved in both salivary gland and hepatocyte invasion by sporozoites. In addition, we will discuss what is known of the role of motility in target cell invasion, since sporozoite invasion of host cells is a dynamic process that is more than just the sum of parasite ligands and host cell receptors. Many lines of evidence suggest that target cell invasion by Apicomplexan parasites is not a passive process in which the parasite induces its internalization by the host cell but instead is an active process rcquiring the actin cytoskeleton of the parasite. An understanding of parasite motility and the way in which interactions between sporozoite ligands and host cell receptors are involved in the movement of the parasite into the cell will therefore lead to a better understanding of host cell invasion.

Original languageEnglish (US)
Title of host publicationMalaria
Subtitle of host publicationMolecular and Clinical Aspects
PublisherCRC Press
Number of pages37
ISBN (Electronic)9781482298246
ISBN (Print)9789057024467
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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