The society for immunotherapy of cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma

Howard L. Kaufman, John M. Kirkwood, F. Stephen Hodi, Sanjiv Agarwala, Thomas Amatruda, Steven D. Bines, Joseph I. Clark, Brendan Curti, Marc S. Ernstoff, Thomas Gajewski, Rene Gonzalez, Laura Jane Hyde, David Lawson, Michael Lotze, Jose Lutzky, Kim Margolin, David F. McDermott, Donald Morton, Anna Pavlick, Jon M. RichardsWilliam Sharfman, Vernon K. Sondak, Jeffrey Sosman, Susan Steel, Ahmad Tarhini, John A. Thompson, Jill Titze, Walter Urba, Richard White, Michael B. Atkins

Research output: Contribution to journalArticle

Abstract

Immunotherapy is associated with durable clinical benefit in patients with melanoma. The goal of this article is to provide evidence-based consensus recommendations for the use of immunotherapy in the clinical management of patients with high-risk and advanced-stage melanoma in the USA. To achieve this goal, the Society for Immunotherapy of Cancer sponsored a panel of melanoma experts-including physicians, nurses, and patient advocates-to develop a consensus for the clinical application of tumour immunotherapy for patients with melanoma. The Institute of Medicine clinical practice guidelines were used as a basis for this consensus development. A systematic literature search was performed for high-impact studies in English between 1992 and 2012 and was supplemented as appropriate by the panel. This consensus report focuses on issues related to patient selection, toxicity management, clinical end points and sequencing or combination of therapy. The literature review and consensus panel voting and discussion were used to generate recommendations for the use of immunotherapy in patients with melanoma, and to assess and rate the strength of the supporting evidence. From the peer-reviewed literature the consensus panel identified a role for interferon-α2b, pegylated-interferon-α2b, interleukin-2 (IL-2) and ipilimumab in the clinical management of melanoma. Expert recommendations for how to incorporate these agents into the therapeutic approach to melanoma are provided in this consensus statement. Tumour immunotherapy is a useful therapeutic strategy in the management of patients with melanoma and evidence-based consensus recommendations for clinical integration are provided and will be updated as warranted.

Original languageEnglish (US)
Pages (from-to)588-598
Number of pages11
JournalNature Reviews Clinical Oncology
Volume10
Issue number10
DOIs
StatePublished - Oct 2013

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Immunotherapy
Melanoma
Consensus
Skin
Neoplasms
Therapeutics
Interferons
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Politics
Practice Guidelines
Patient Selection
Interleukin-2
Nurses
Physicians

ASJC Scopus subject areas

  • Oncology

Cite this

Kaufman, H. L., Kirkwood, J. M., Hodi, F. S., Agarwala, S., Amatruda, T., Bines, S. D., ... Atkins, M. B. (2013). The society for immunotherapy of cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. Nature Reviews Clinical Oncology, 10(10), 588-598. https://doi.org/10.1038/nrclinonc.2013.153

The society for immunotherapy of cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. / Kaufman, Howard L.; Kirkwood, John M.; Hodi, F. Stephen; Agarwala, Sanjiv; Amatruda, Thomas; Bines, Steven D.; Clark, Joseph I.; Curti, Brendan; Ernstoff, Marc S.; Gajewski, Thomas; Gonzalez, Rene; Hyde, Laura Jane; Lawson, David; Lotze, Michael; Lutzky, Jose; Margolin, Kim; McDermott, David F.; Morton, Donald; Pavlick, Anna; Richards, Jon M.; Sharfman, William; Sondak, Vernon K.; Sosman, Jeffrey; Steel, Susan; Tarhini, Ahmad; Thompson, John A.; Titze, Jill; Urba, Walter; White, Richard; Atkins, Michael B.

In: Nature Reviews Clinical Oncology, Vol. 10, No. 10, 10.2013, p. 588-598.

Research output: Contribution to journalArticle

Kaufman, HL, Kirkwood, JM, Hodi, FS, Agarwala, S, Amatruda, T, Bines, SD, Clark, JI, Curti, B, Ernstoff, MS, Gajewski, T, Gonzalez, R, Hyde, LJ, Lawson, D, Lotze, M, Lutzky, J, Margolin, K, McDermott, DF, Morton, D, Pavlick, A, Richards, JM, Sharfman, W, Sondak, VK, Sosman, J, Steel, S, Tarhini, A, Thompson, JA, Titze, J, Urba, W, White, R & Atkins, MB 2013, 'The society for immunotherapy of cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma', Nature Reviews Clinical Oncology, vol. 10, no. 10, pp. 588-598. https://doi.org/10.1038/nrclinonc.2013.153
Kaufman, Howard L. ; Kirkwood, John M. ; Hodi, F. Stephen ; Agarwala, Sanjiv ; Amatruda, Thomas ; Bines, Steven D. ; Clark, Joseph I. ; Curti, Brendan ; Ernstoff, Marc S. ; Gajewski, Thomas ; Gonzalez, Rene ; Hyde, Laura Jane ; Lawson, David ; Lotze, Michael ; Lutzky, Jose ; Margolin, Kim ; McDermott, David F. ; Morton, Donald ; Pavlick, Anna ; Richards, Jon M. ; Sharfman, William ; Sondak, Vernon K. ; Sosman, Jeffrey ; Steel, Susan ; Tarhini, Ahmad ; Thompson, John A. ; Titze, Jill ; Urba, Walter ; White, Richard ; Atkins, Michael B. / The society for immunotherapy of cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. In: Nature Reviews Clinical Oncology. 2013 ; Vol. 10, No. 10. pp. 588-598.
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