The Sleep-Immunity Relationship

Charlene E. Gamaldo; Annum K. Shaikh; Justin C. McArthur

doi:10.1016/j.ncl.2012.08.007

The Sleep-Immunity Relationship

Charlene E. Gamaldo, Annum K. Shaikh, Justin C. McArthur

School of Medicine

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.

Original language	English (US)
Pages (from-to)	1313-1343
Number of pages	31
Journal	Neurologic clinics
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.ncl.2012.08.007
State	Published - Nov 2012

Keywords

Apnea
Cytokines
Immunity
Infectious diseases
Inflammation
Insomnia
Interleukins
Sleep

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2012.08.007

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title = "The Sleep-Immunity Relationship",

abstract = "Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.",

keywords = "Apnea, Cytokines, Immunity, Infectious diseases, Inflammation, Insomnia, Interleukins, Sleep",

author = "Gamaldo, {Charlene E.} and Shaikh, {Annum K.} and McArthur, {Justin C.}",

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AU - Gamaldo, Charlene E.

AU - Shaikh, Annum K.

AU - McArthur, Justin C.

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N2 - Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.

AB - Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.

KW - Apnea

KW - Cytokines

KW - Immunity

KW - Infectious diseases

KW - Inflammation

KW - Insomnia

KW - Interleukins

KW - Sleep

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JO - Neurologic clinics

JF - Neurologic clinics

IS - 4

ER -

The Sleep-Immunity Relationship

Abstract

Keywords

ASJC Scopus subject areas

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