The Sleep-Immunity Relationship

Research output: Contribution to journalArticle


Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.

Original languageEnglish (US)
Pages (from-to)1313-1343
Number of pages31
JournalNeurologic Clinics
Issue number4
Publication statusPublished - Nov 2012



  • Apnea
  • Cytokines
  • Immunity
  • Infectious diseases
  • Inflammation
  • Insomnia
  • Interleukins
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology

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