The skin stage of malaria infection

Biology and relevance to the malaria vaccine effort

Research output: Contribution to journalArticle

Abstract

Plasmodium sporozoites, the infective stage of the malaria parasite, are injected into the mammalian host by mosquitoes and travel to the liver where they invade hepatocytes. Recent studies demonstrating that sporozoites are inoculated into the skin, remain there for hours before exiting and that 20% of the inoculum goes to the lymph node draining the inoculation site, suggest that there is a 'skin stage' to malaria infection that may set the stage for subsequent host responses to the parasite. Here, we present an overview of what is currently known about sporozoite-host interactions at the inoculation site and the draining lymph node, and discuss the impact of the skin stage of malaria on immunity to pre-erythrocytic stages and malaria vaccine design.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalFuture Microbiology
Volume3
Issue number3
DOIs
StatePublished - Jun 2008

Fingerprint

Malaria Vaccines
Sporozoites
Malaria
Skin
Parasites
Infection
Lymph Nodes
Plasmodium
Culicidae
Hepatocytes
Immunity
Liver

Keywords

  • Dendritic cells
  • Dermal injection
  • Malaria
  • Plasmodium
  • Skin
  • Sporozoite
  • T-cell priming
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

The skin stage of malaria infection : Biology and relevance to the malaria vaccine effort. / Sinnis, Photini; Zavala, Fidel P.

In: Future Microbiology, Vol. 3, No. 3, 06.2008, p. 275-278.

Research output: Contribution to journalArticle

@article{6129edb46e5c416a9215eb8bf6667fb4,
title = "The skin stage of malaria infection: Biology and relevance to the malaria vaccine effort",
abstract = "Plasmodium sporozoites, the infective stage of the malaria parasite, are injected into the mammalian host by mosquitoes and travel to the liver where they invade hepatocytes. Recent studies demonstrating that sporozoites are inoculated into the skin, remain there for hours before exiting and that 20{\%} of the inoculum goes to the lymph node draining the inoculation site, suggest that there is a 'skin stage' to malaria infection that may set the stage for subsequent host responses to the parasite. Here, we present an overview of what is currently known about sporozoite-host interactions at the inoculation site and the draining lymph node, and discuss the impact of the skin stage of malaria on immunity to pre-erythrocytic stages and malaria vaccine design.",
keywords = "Dendritic cells, Dermal injection, Malaria, Plasmodium, Skin, Sporozoite, T-cell priming, Vaccine",
author = "Photini Sinnis and Zavala, {Fidel P}",
year = "2008",
month = "6",
doi = "10.2217/17460913.3.3.275",
language = "English (US)",
volume = "3",
pages = "275--278",
journal = "Future Microbiology",
issn = "1746-0913",
publisher = "Future Medicine Ltd.",
number = "3",

}

TY - JOUR

T1 - The skin stage of malaria infection

T2 - Biology and relevance to the malaria vaccine effort

AU - Sinnis, Photini

AU - Zavala, Fidel P

PY - 2008/6

Y1 - 2008/6

N2 - Plasmodium sporozoites, the infective stage of the malaria parasite, are injected into the mammalian host by mosquitoes and travel to the liver where they invade hepatocytes. Recent studies demonstrating that sporozoites are inoculated into the skin, remain there for hours before exiting and that 20% of the inoculum goes to the lymph node draining the inoculation site, suggest that there is a 'skin stage' to malaria infection that may set the stage for subsequent host responses to the parasite. Here, we present an overview of what is currently known about sporozoite-host interactions at the inoculation site and the draining lymph node, and discuss the impact of the skin stage of malaria on immunity to pre-erythrocytic stages and malaria vaccine design.

AB - Plasmodium sporozoites, the infective stage of the malaria parasite, are injected into the mammalian host by mosquitoes and travel to the liver where they invade hepatocytes. Recent studies demonstrating that sporozoites are inoculated into the skin, remain there for hours before exiting and that 20% of the inoculum goes to the lymph node draining the inoculation site, suggest that there is a 'skin stage' to malaria infection that may set the stage for subsequent host responses to the parasite. Here, we present an overview of what is currently known about sporozoite-host interactions at the inoculation site and the draining lymph node, and discuss the impact of the skin stage of malaria on immunity to pre-erythrocytic stages and malaria vaccine design.

KW - Dendritic cells

KW - Dermal injection

KW - Malaria

KW - Plasmodium

KW - Skin

KW - Sporozoite

KW - T-cell priming

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=46049083075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46049083075&partnerID=8YFLogxK

U2 - 10.2217/17460913.3.3.275

DO - 10.2217/17460913.3.3.275

M3 - Article

VL - 3

SP - 275

EP - 278

JO - Future Microbiology

JF - Future Microbiology

SN - 1746-0913

IS - 3

ER -