The sirtuin family's role in aging and age-associated pathologies

Jessica A. Hall, John E. Dominy, Yoonjin Lee, Pere Puigserver

Research output: Contribution to journalArticlepeer-review

Abstract

The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.

Original languageEnglish (US)
Pages (from-to)973-979
Number of pages7
JournalJournal of Clinical Investigation
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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