TY - JOUR
T1 - The Sinonasal Tract
T2 - Another Potential "Hot Spot" for Carcinomas with Transcriptionally-Active Human Papillomavirus
AU - Lewis, James S.
AU - Westra, William H.
AU - Thompson, Lester D.R.
AU - Barnes, Leon
AU - Cardesa, Antonio
AU - Hunt, Jennifer L.
AU - Williams, Michelle D.
AU - Slootweg, Pieter J.
AU - Triantafyllou, Asterios
AU - Woolgar, Julia A.
AU - Devaney, Kenneth O.
AU - Rinaldo, Alessandra
AU - Ferlito, Alfio
PY - 2014/9
Y1 - 2014/9
N2 - While high risk human papillomavirus (HPV) is well established as causative and clinically important for squamous cell carcinoma (SCC) of the oropharynx, its role in non-oropharyngeal head and neck SCC is much less clearly elucidated. In the sinonasal region, in particular, although it is a relatively uncommon site for SCC, as many as 20 % of SCC harbor transcriptionally-active high risk HPV. These tumors almost always have a nonkeratinizing morphology and may have a better prognosis. In addition, specific variants of SCC as well as other rare carcinoma types, when arising in the sinonasal tract, can harbor transcriptionally-active HPV. This article reviews the current literature on HPV in sinonasal carcinomas, attempts to more clearly demonstrate what tumors have it and how this relates to possible precursor lesions like inverted papilloma, and discusses the possible clinical ramifications of the presence of the virus.
AB - While high risk human papillomavirus (HPV) is well established as causative and clinically important for squamous cell carcinoma (SCC) of the oropharynx, its role in non-oropharyngeal head and neck SCC is much less clearly elucidated. In the sinonasal region, in particular, although it is a relatively uncommon site for SCC, as many as 20 % of SCC harbor transcriptionally-active high risk HPV. These tumors almost always have a nonkeratinizing morphology and may have a better prognosis. In addition, specific variants of SCC as well as other rare carcinoma types, when arising in the sinonasal tract, can harbor transcriptionally-active HPV. This article reviews the current literature on HPV in sinonasal carcinomas, attempts to more clearly demonstrate what tumors have it and how this relates to possible precursor lesions like inverted papilloma, and discusses the possible clinical ramifications of the presence of the virus.
KW - Human papillomavirus
KW - Nonkeratinizing
KW - Sinonasal
KW - Squamous cell carcinoma
KW - p16
UR - http://www.scopus.com/inward/record.url?scp=84905731675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905731675&partnerID=8YFLogxK
U2 - 10.1007/s12105-013-0514-4
DO - 10.1007/s12105-013-0514-4
M3 - Review article
C2 - 24338611
AN - SCOPUS:84905731675
SN - 1936-055X
VL - 8
SP - 241
EP - 249
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 3
ER -