The Sinonasal Tract: Another Potential "Hot Spot" for Carcinomas with Transcriptionally-Active Human Papillomavirus

James S. Lewis, William H. Westra, Lester D.R. Thompson, Leon Barnes, Antonio Cardesa, Jennifer L. Hunt, Michelle D. Williams, Pieter J. Slootweg, Asterios Triantafyllou, Julia A. Woolgar, Kenneth O. Devaney, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

Abstract

While high risk human papillomavirus (HPV) is well established as causative and clinically important for squamous cell carcinoma (SCC) of the oropharynx, its role in non-oropharyngeal head and neck SCC is much less clearly elucidated. In the sinonasal region, in particular, although it is a relatively uncommon site for SCC, as many as 20 % of SCC harbor transcriptionally-active high risk HPV. These tumors almost always have a nonkeratinizing morphology and may have a better prognosis. In addition, specific variants of SCC as well as other rare carcinoma types, when arising in the sinonasal tract, can harbor transcriptionally-active HPV. This article reviews the current literature on HPV in sinonasal carcinomas, attempts to more clearly demonstrate what tumors have it and how this relates to possible precursor lesions like inverted papilloma, and discusses the possible clinical ramifications of the presence of the virus.

Original languageEnglish (US)
Pages (from-to)241-249
Number of pages9
JournalHead and Neck Pathology
Volume8
Issue number3
DOIs
StatePublished - Sep 2014

Keywords

  • Human papillomavirus
  • Nonkeratinizing
  • Sinonasal
  • Squamous cell carcinoma
  • p16

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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