The significance of unstable chromosomes in colorectal cancer

Harith Rajagopalan; Martin A. Nowak; Bert Vogelstein; Christoph Lengauer

doi:10.1038/nrc1165

The significance of unstable chromosomes in colorectal cancer

Harith Rajagopalan, Martin A. Nowak, Bert Vogelstein, Christoph Lengauer

School of Medicine

Research output: Contribution to journal › Review article › peer-review

395 Scopus citations

Abstract

A very large fraction of cancers have an abnormal genetic content, called aneuploidy, which is characterized by changes in chromosome structure and number. One explanation for this aneuploidy is chromosomal instability, in which cancer cells gain or lose whole chromosomes or large fractions of chromosomes at a greatly increased rate compared with normal cells. Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis.

Original language	English (US)
Pages (from-to)	695-701
Number of pages	7
Journal	Nature Reviews Cancer
Volume	3
Issue number	9
DOIs	https://doi.org/10.1038/nrc1165
State	Published - Sep 2003

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc1165

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The significance of unstable chromosomes in colorectal cancer

Abstract

ASJC Scopus subject areas

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